Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

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Detalles Bibliográficos
Autores principales: Hyunji Moon, Chanhyuk Min, Gayoung Kim, Deokhwan Kim, Kwanhyeong Kim, Sang-Ah Lee, Byeongjin Moon, Susumin Yang, Juyeon Lee, Seung-Joo Yang, Steve K. Cho, Gwangrog Lee, Chang Sup Lee, Chul-Seung Park, Daeho Park
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e974b64c64804ac5944f1149649c6f51
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