Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

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Bibliographic Details
Main Authors: Hyunji Moon, Chanhyuk Min, Gayoung Kim, Deokhwan Kim, Kwanhyeong Kim, Sang-Ah Lee, Byeongjin Moon, Susumin Yang, Juyeon Lee, Seung-Joo Yang, Steve K. Cho, Gwangrog Lee, Chang Sup Lee, Chul-Seung Park, Daeho Park
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/e974b64c64804ac5944f1149649c6f51
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Internet

https://doaj.org/article/e974b64c64804ac5944f1149649c6f51

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