Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis

Abstract Preoperative vocal cord palsy (VCP) may indicate locally invasive papillary thyroid cancer (PTC); using this relationship, we evaluated the clinical outcomes and risk factors for recurrence in post-thyroidectomy T4a PTC patients with recurrent laryngeal nerve (RLN) involvement. We retrospec...

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Autores principales:	Han-Seul Na, Hyun-Keun Kwon, Sung-Chan Shin, Yong-Il Cheon, Myeonggu Seo, Jin-Choon Lee, Eui-Suk Sung, Minhyung Lee, In-Joo Kim, Bo Hyun Kim, Byung-Joo Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e97acda2d81d494dbbb95573d60d37cb
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spelling	oai:doaj.org-article:e97acda2d81d494dbbb95573d60d37cb2021-12-02T16:35:55ZClinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis10.1038/s41598-021-86226-x2045-2322https://doaj.org/article/e97acda2d81d494dbbb95573d60d37cb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86226-xhttps://doaj.org/toc/2045-2322Abstract Preoperative vocal cord palsy (VCP) may indicate locally invasive papillary thyroid cancer (PTC); using this relationship, we evaluated the clinical outcomes and risk factors for recurrence in post-thyroidectomy T4a PTC patients with recurrent laryngeal nerve (RLN) involvement. We retrospectively investigated thyroidectomy patients, recorded their clinical factors, recurrence rate, and pathological findings, and analysed the relationship between recurrence rate and clinical factors. Of 72 patients, 37 (51%) had preoperative VCP and 35 (49%) had normal preoperative vocal cord movement with confirmed intraoperative RLN invasion. Tracheal and esophageal invasion was observed in 13 (18%) and 15 (21%) patients, respectively. Thyroid cancer recurred in 18 (25%) patients over 58 months, resulting in 2 (3%) deaths. Recurrence was not associated with surgical extent, organ invasion, enlarged tumour size, or lymph node infiltration (p > 0.05). The recurrence rate was significantly higher in patients with positive resection margins (p < 0.05). T4a PTC patients with RLN involvement showed a poor prognosis. The recurrence rate was not affected by preoperative VCP, intraoperative detection of RLN invasion, nerve resection, nerve preservation by shaving, lymph node metastasis, or tracheal or esophageal invasion. The most important prognostic factor for recurrence was a positive resection margin.Han-Seul NaHyun-Keun KwonSung-Chan ShinYong-Il CheonMyeonggu SeoJin-Choon LeeEui-Suk SungMinhyung LeeIn-Joo KimBo Hyun KimByung-Joo LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Han-Seul Na Hyun-Keun Kwon Sung-Chan Shin Yong-Il Cheon Myeonggu Seo Jin-Choon Lee Eui-Suk Sung Minhyung Lee In-Joo Kim Bo Hyun Kim Byung-Joo Lee Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
description	Abstract Preoperative vocal cord palsy (VCP) may indicate locally invasive papillary thyroid cancer (PTC); using this relationship, we evaluated the clinical outcomes and risk factors for recurrence in post-thyroidectomy T4a PTC patients with recurrent laryngeal nerve (RLN) involvement. We retrospectively investigated thyroidectomy patients, recorded their clinical factors, recurrence rate, and pathological findings, and analysed the relationship between recurrence rate and clinical factors. Of 72 patients, 37 (51%) had preoperative VCP and 35 (49%) had normal preoperative vocal cord movement with confirmed intraoperative RLN invasion. Tracheal and esophageal invasion was observed in 13 (18%) and 15 (21%) patients, respectively. Thyroid cancer recurred in 18 (25%) patients over 58 months, resulting in 2 (3%) deaths. Recurrence was not associated with surgical extent, organ invasion, enlarged tumour size, or lymph node infiltration (p > 0.05). The recurrence rate was significantly higher in patients with positive resection margins (p < 0.05). T4a PTC patients with RLN involvement showed a poor prognosis. The recurrence rate was not affected by preoperative VCP, intraoperative detection of RLN invasion, nerve resection, nerve preservation by shaving, lymph node metastasis, or tracheal or esophageal invasion. The most important prognostic factor for recurrence was a positive resection margin.
format	article
author	Han-Seul Na Hyun-Keun Kwon Sung-Chan Shin Yong-Il Cheon Myeonggu Seo Jin-Choon Lee Eui-Suk Sung Minhyung Lee In-Joo Kim Bo Hyun Kim Byung-Joo Lee
author_facet	Han-Seul Na Hyun-Keun Kwon Sung-Chan Shin Yong-Il Cheon Myeonggu Seo Jin-Choon Lee Eui-Suk Sung Minhyung Lee In-Joo Kim Bo Hyun Kim Byung-Joo Lee
author_sort	Han-Seul Na
title	Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
title_short	Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
title_full	Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
title_fullStr	Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
title_full_unstemmed	Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
title_sort	clinical outcomes of t4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e97acda2d81d494dbbb95573d60d37cb
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Clinical outcomes of T4a papillary thyroid cancer with recurrent laryngeal nerve involvement: a retrospective analysis

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