Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus

Type 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better...

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Autores principales:	Carmen Purdel, Anca Ungurianu, Denisa Margina
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	omega-3 PUFAs dietary intake EPA DHA type 1 diabetes mellitus metabolomics Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e97c80e9b2e44087b4515268182188ba
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spelling	oai:doaj.org-article:e97c80e9b2e44087b4515268182188ba2021-12-03T05:56:14ZMetabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus2296-889X10.3389/fmolb.2021.783065https://doaj.org/article/e97c80e9b2e44087b4515268182188ba2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.783065/fullhttps://doaj.org/toc/2296-889XType 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better understanding of the potential role of ω-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by ω-3 PUFAs and the beneficial effects of ω-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes.Carmen PurdelAnca UngurianuDenisa MarginaFrontiers Media S.A.articleomega-3 PUFAsdietary intakeEPADHAtype 1 diabetes mellitusmetabolomicsBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	omega-3 PUFAs dietary intake EPA DHA type 1 diabetes mellitus metabolomics Biology (General) QH301-705.5
spellingShingle	omega-3 PUFAs dietary intake EPA DHA type 1 diabetes mellitus metabolomics Biology (General) QH301-705.5 Carmen Purdel Anca Ungurianu Denisa Margina Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
description	Type 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better understanding of the potential role of ω-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by ω-3 PUFAs and the beneficial effects of ω-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes.
format	article
author	Carmen Purdel Anca Ungurianu Denisa Margina
author_facet	Carmen Purdel Anca Ungurianu Denisa Margina
author_sort	Carmen Purdel
title	Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_short	Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_full	Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_fullStr	Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_full_unstemmed	Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_sort	metabolic and metabolomic insights regarding the omega-3 pufas intake in type 1 diabetes mellitus
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e97c80e9b2e44087b4515268182188ba
work_keys_str_mv	AT carmenpurdel metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus AT ancaungurianu metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus AT denisamargina metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus
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Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus

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