Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus

Type 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better...

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Autores principales: Carmen Purdel, Anca Ungurianu, Denisa Margina
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
EPA
DHA
Acceso en línea:https://doaj.org/article/e97c80e9b2e44087b4515268182188ba
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spelling oai:doaj.org-article:e97c80e9b2e44087b4515268182188ba2021-12-03T05:56:14ZMetabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus2296-889X10.3389/fmolb.2021.783065https://doaj.org/article/e97c80e9b2e44087b4515268182188ba2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.783065/fullhttps://doaj.org/toc/2296-889XType 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better understanding of the potential role of ω-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by ω-3 PUFAs and the beneficial effects of ω-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes.Carmen PurdelAnca UngurianuDenisa MarginaFrontiers Media S.A.articleomega-3 PUFAsdietary intakeEPADHAtype 1 diabetes mellitusmetabolomicsBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution DOAJ
collection DOAJ
language EN
topic omega-3 PUFAs
dietary intake
EPA
DHA
type 1 diabetes mellitus
metabolomics
Biology (General)
QH301-705.5
spellingShingle omega-3 PUFAs
dietary intake
EPA
DHA
type 1 diabetes mellitus
metabolomics
Biology (General)
QH301-705.5
Carmen Purdel
Anca Ungurianu
Denisa Margina
Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
description Type 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better understanding of the potential role of ω-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by ω-3 PUFAs and the beneficial effects of ω-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes.
format article
author Carmen Purdel
Anca Ungurianu
Denisa Margina
author_facet Carmen Purdel
Anca Ungurianu
Denisa Margina
author_sort Carmen Purdel
title Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_short Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_full Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_fullStr Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_full_unstemmed Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
title_sort metabolic and metabolomic insights regarding the omega-3 pufas intake in type 1 diabetes mellitus
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/e97c80e9b2e44087b4515268182188ba
work_keys_str_mv AT carmenpurdel metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus
AT ancaungurianu metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus
AT denisamargina metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus
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