Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:e97c80e9b2e44087b4515268182188ba2021-12-03T05:56:14ZMetabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus2296-889X10.3389/fmolb.2021.783065https://doaj.org/article/e97c80e9b2e44087b4515268182188ba2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.783065/fullhttps://doaj.org/toc/2296-889XType 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better understanding of the potential role of ω-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by ω-3 PUFAs and the beneficial effects of ω-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes.Carmen PurdelAnca UngurianuDenisa MarginaFrontiers Media S.A.articleomega-3 PUFAsdietary intakeEPADHAtype 1 diabetes mellitusmetabolomicsBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021) |
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omega-3 PUFAs dietary intake EPA DHA type 1 diabetes mellitus metabolomics Biology (General) QH301-705.5 |
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omega-3 PUFAs dietary intake EPA DHA type 1 diabetes mellitus metabolomics Biology (General) QH301-705.5 Carmen Purdel Anca Ungurianu Denisa Margina Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus |
description |
Type 1 diabetes mellitus (T1DM) is currently considered an autoimmune disease characterized by the destruction of pancreatic β-cells, insulin deficiency, and dysglycemia. Dietary factors, including omega-3 polyunsaturated fatty acids (ω-3 PUFAs), were reported to influence T1DM. Therefore, a better understanding of the potential role of ω-3 PUFAs in the development and progression of T1DM will help to improve the clinical management of the disease. In this review, we explored the current understanding of molecular mechanisms and signaling pathways induced by ω-3 PUFAs and the beneficial effects of ω-3 PUFAs intake in the prevention and treatment of T1DM, as well as the underlying possible metabolomic (lipidomics) changes. |
format |
article |
author |
Carmen Purdel Anca Ungurianu Denisa Margina |
author_facet |
Carmen Purdel Anca Ungurianu Denisa Margina |
author_sort |
Carmen Purdel |
title |
Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus |
title_short |
Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus |
title_full |
Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus |
title_fullStr |
Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus |
title_full_unstemmed |
Metabolic and Metabolomic Insights Regarding the Omega-3 PUFAs Intake in Type 1 Diabetes Mellitus |
title_sort |
metabolic and metabolomic insights regarding the omega-3 pufas intake in type 1 diabetes mellitus |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/e97c80e9b2e44087b4515268182188ba |
work_keys_str_mv |
AT carmenpurdel metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus AT ancaungurianu metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus AT denisamargina metabolicandmetabolomicinsightsregardingtheomega3pufasintakeintype1diabetesmellitus |
_version_ |
1718373906084003840 |