Congenital deafness is associated with specific somatosensory deficits in adolescents

Abstract Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14–20 years old) compar...

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Autores principales:	Rabih Moshourab, Valérie Bégay, Christiane Wetzel, Jan Walcher, Steven Middleton, Manfred Gross, Gary R. Lewin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e97f40f3b7be4000b022cf961430c225
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spelling	oai:doaj.org-article:e97f40f3b7be4000b022cf961430c2252021-12-02T16:06:30ZCongenital deafness is associated with specific somatosensory deficits in adolescents10.1038/s41598-017-04074-02045-2322https://doaj.org/article/e97f40f3b7be4000b022cf961430c2252017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04074-0https://doaj.org/toc/2045-2322Abstract Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14–20 years old) compared to age-matched individuals with congenital hearing loss. Sensory testing was performed on the dominant hand of 111 individuals with normal hearing and 36 with congenital hearing loss. Subjects with congenital deafness were characterized by significantly higher vibration detection thresholds at 10 Hz (2-fold increase, P < 0.001) and 125 Hz (P < 0.05) compared to controls. These sensory changes were not accompanied by any major change in measures of pain perception. We also observed a highly significant reduction (30% compared to controls p < 0.001) in the ability of hearing impaired individual’s ability to detect cooling which was not accompanied by changes in warm detection. At least 60% of children with non-syndromic hearing loss showed very significant loss of vibration detection ability (at 10 Hz) compared to age-matched controls. We thus propose that many pathogenic mutations that cause childhood onset deafness may also play a role in the development or functional maintenance of somatic mechanoreceptors.Rabih MoshourabValérie BégayChristiane WetzelJan WalcherSteven MiddletonManfred GrossGary R. LewinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rabih Moshourab Valérie Bégay Christiane Wetzel Jan Walcher Steven Middleton Manfred Gross Gary R. Lewin Congenital deafness is associated with specific somatosensory deficits in adolescents
description	Abstract Hearing and touch represent two distinct sensory systems that both rely on the transformation of mechanical force into electrical signals. Here we used a battery of quantitative sensory tests to probe touch, thermal and pain sensitivity in a young control population (14–20 years old) compared to age-matched individuals with congenital hearing loss. Sensory testing was performed on the dominant hand of 111 individuals with normal hearing and 36 with congenital hearing loss. Subjects with congenital deafness were characterized by significantly higher vibration detection thresholds at 10 Hz (2-fold increase, P < 0.001) and 125 Hz (P < 0.05) compared to controls. These sensory changes were not accompanied by any major change in measures of pain perception. We also observed a highly significant reduction (30% compared to controls p < 0.001) in the ability of hearing impaired individual’s ability to detect cooling which was not accompanied by changes in warm detection. At least 60% of children with non-syndromic hearing loss showed very significant loss of vibration detection ability (at 10 Hz) compared to age-matched controls. We thus propose that many pathogenic mutations that cause childhood onset deafness may also play a role in the development or functional maintenance of somatic mechanoreceptors.
format	article
author	Rabih Moshourab Valérie Bégay Christiane Wetzel Jan Walcher Steven Middleton Manfred Gross Gary R. Lewin
author_facet	Rabih Moshourab Valérie Bégay Christiane Wetzel Jan Walcher Steven Middleton Manfred Gross Gary R. Lewin
author_sort	Rabih Moshourab
title	Congenital deafness is associated with specific somatosensory deficits in adolescents
title_short	Congenital deafness is associated with specific somatosensory deficits in adolescents
title_full	Congenital deafness is associated with specific somatosensory deficits in adolescents
title_fullStr	Congenital deafness is associated with specific somatosensory deficits in adolescents
title_full_unstemmed	Congenital deafness is associated with specific somatosensory deficits in adolescents
title_sort	congenital deafness is associated with specific somatosensory deficits in adolescents
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e97f40f3b7be4000b022cf961430c225
work_keys_str_mv	AT rabihmoshourab congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents AT valeriebegay congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents AT christianewetzel congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents AT janwalcher congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents AT stevenmiddleton congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents AT manfredgross congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents AT garyrlewin congenitaldeafnessisassociatedwithspecificsomatosensorydeficitsinadolescents
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Congenital deafness is associated with specific somatosensory deficits in adolescents

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