Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study

New benzimidazole analogues (1–18) were synthesized and characterized through different spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogues were screened for β-glucuronidase inhibitory potential. All analogues showed varied degree of inhibitory potentials with IC50 values ran...

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Autores principales: Muhammad Taha, Aftab Ahmad Khan, Fazal Rahim, Syahrul Imran, Mohammed Salahuddin, Nizam Uddin, Khalid Mohammed Khan, Syed Adnan Ali Shah, Ameeduzzafar Zafar, Zainul Amiruddin Zakaria
Formato: article
Lenguaje:EN
Publicado: Elsevier 2022
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Acceso en línea:https://doaj.org/article/e982162410ef49c6bb3edb31ee059b99
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