FAM111A protects replication forks from protein obstacles via its trypsin-like domain

DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication forks.

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Autores principales:	Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
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spelling	oai:doaj.org-article:e9822e13f0724bd0b06193f6b527c8952021-12-02T17:31:09ZFAM111A protects replication forks from protein obstacles via its trypsin-like domain10.1038/s41467-020-15170-72041-1723https://doaj.org/article/e9822e13f0724bd0b06193f6b527c8952020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15170-7https://doaj.org/toc/2041-1723DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication forks.Yusuke KojimaYuka MachidaSowmiya PalaniThomas R. CaulfieldEvette S. RadiskyScott H. KaufmannYuichi J. MachidaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Kojima Yuka Machida Sowmiya Palani Thomas R. Caulfield Evette S. Radisky Scott H. Kaufmann Yuichi J. Machida FAM111A protects replication forks from protein obstacles via its trypsin-like domain
description	DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication forks.
format	article
author	Yusuke Kojima Yuka Machida Sowmiya Palani Thomas R. Caulfield Evette S. Radisky Scott H. Kaufmann Yuichi J. Machida
author_facet	Yusuke Kojima Yuka Machida Sowmiya Palani Thomas R. Caulfield Evette S. Radisky Scott H. Kaufmann Yuichi J. Machida
author_sort	Yusuke Kojima
title	FAM111A protects replication forks from protein obstacles via its trypsin-like domain
title_short	FAM111A protects replication forks from protein obstacles via its trypsin-like domain
title_full	FAM111A protects replication forks from protein obstacles via its trypsin-like domain
title_fullStr	FAM111A protects replication forks from protein obstacles via its trypsin-like domain
title_full_unstemmed	FAM111A protects replication forks from protein obstacles via its trypsin-like domain
title_sort	fam111a protects replication forks from protein obstacles via its trypsin-like domain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e9822e13f0724bd0b06193f6b527c895
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FAM111A protects replication forks from protein obstacles via its trypsin-like domain

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