Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, present its solution NMR structure and show how HusA c...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e9830d61b97349769f8267ca4421698e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, present its solution NMR structure and show how HusA can be exploited as a drug target. |
|---|