Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis

The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, present its solution NMR structure and show how HusA c...

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Autores principales:	Jin-Long Gao, Ann H. Kwan, Anthony Yammine, Xiaoyan Zhou, Jill Trewhella, Barbara M. Hugrass, Daniel A. T. Collins, James Horne, Ping Ye, Derek Harty, Ky-Anh Nguyen, David A. Gell, Neil Hunter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9830d61b97349769f8267ca4421698e
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spelling	oai:doaj.org-article:e9830d61b97349769f8267ca4421698e2021-12-02T15:34:27ZStructural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis10.1038/s41467-018-06470-02041-1723https://doaj.org/article/e9830d61b97349769f8267ca4421698e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06470-0https://doaj.org/toc/2041-1723The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, present its solution NMR structure and show how HusA can be exploited as a drug target.Jin-Long GaoAnn H. KwanAnthony YammineXiaoyan ZhouJill TrewhellaBarbara M. HugrassDaniel A. T. CollinsJames HornePing YeDerek HartyKy-Anh NguyenDavid A. GellNeil HunterNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin-Long Gao Ann H. Kwan Anthony Yammine Xiaoyan Zhou Jill Trewhella Barbara M. Hugrass Daniel A. T. Collins James Horne Ping Ye Derek Harty Ky-Anh Nguyen David A. Gell Neil Hunter Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
description	The pathogenic bacterium Porphyromonas gingivalis causes periodontal disease and depends on porphyrin from host sources. Here the authors show that the P. gingivalis haem uptake system protein A (HusA) mediates the uptake of exogenous porphyrin, present its solution NMR structure and show how HusA can be exploited as a drug target.
format	article
author	Jin-Long Gao Ann H. Kwan Anthony Yammine Xiaoyan Zhou Jill Trewhella Barbara M. Hugrass Daniel A. T. Collins James Horne Ping Ye Derek Harty Ky-Anh Nguyen David A. Gell Neil Hunter
author_facet	Jin-Long Gao Ann H. Kwan Anthony Yammine Xiaoyan Zhou Jill Trewhella Barbara M. Hugrass Daniel A. T. Collins James Horne Ping Ye Derek Harty Ky-Anh Nguyen David A. Gell Neil Hunter
author_sort	Jin-Long Gao
title	Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
title_short	Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
title_full	Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
title_fullStr	Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
title_full_unstemmed	Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis
title_sort	structural properties of a haemophore facilitate targeted elimination of the pathogen porphyromonas gingivalis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e9830d61b97349769f8267ca4421698e
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Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis

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