Inflammation-based assessment for the risk stratification of mortality in patients with heart failure

Abstract The Glasgow Prognostic Score (GPS) has been established as a useful resource to evaluate inflammation and malnutrition and predict prognosis in several cancers. However, its prognostic significance in patients with heart failure (HF) is not well established. To investigate the association b...

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Autores principales:	Tadashi Itagaki, Hirohiko Motoki, Kyuhachi Otagiri, Keisuke Machida, Takahiro Takeuchi, Masafumi Kanai, Kazuhiro Kimura, Satoko Higuchi, Masatoshi Minamisawa, Hiroshi Kitabayashi, Koichiro Kuwahara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9872d6425274422a8045d7d8f238906
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spelling	oai:doaj.org-article:e9872d6425274422a8045d7d8f2389062021-12-02T16:50:24ZInflammation-based assessment for the risk stratification of mortality in patients with heart failure10.1038/s41598-021-94525-62045-2322https://doaj.org/article/e9872d6425274422a8045d7d8f2389062021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94525-6https://doaj.org/toc/2045-2322Abstract The Glasgow Prognostic Score (GPS) has been established as a useful resource to evaluate inflammation and malnutrition and predict prognosis in several cancers. However, its prognostic significance in patients with heart failure (HF) is not well established. To investigate the association between the GPS and mortality in patients with HF, we assessed 870 patients who were 20 years old and more and had been admitted for acute decompensated HF. The GPS ranged from 0 to 2 points as previously reported. Over the 18-month follow-up (follow-up rate, 83.9%), 143 patients died. Increasing GPS was associated with higher HF severity assessed by New York Heart Association functional class and B-type natriuretic peptide (BNP) levels. Kaplan–Meier analysis showed significant associations for mortality and increased GPS. In multivariate analysis, compared to the GPS 0 group, the GPS 2 group was associated with high mortality (hazard ratio 2.92, 95% confidence interval 1.77–4.81, p < 0.001) after adjustment for age, sex, blood pressure, HF history, HF severity, hemoglobin, renal function, sodium, BNP, left ventricular ejection fraction, and anti-HF medications. In conclusion, high GPS was significantly associated with worse prognosis in patients with HF. Inflammation-based assessment by the GPS may enable simple evaluation of HF severity and prognosis.Tadashi ItagakiHirohiko MotokiKyuhachi OtagiriKeisuke MachidaTakahiro TakeuchiMasafumi KanaiKazuhiro KimuraSatoko HiguchiMasatoshi MinamisawaHiroshi KitabayashiKoichiro KuwaharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tadashi Itagaki Hirohiko Motoki Kyuhachi Otagiri Keisuke Machida Takahiro Takeuchi Masafumi Kanai Kazuhiro Kimura Satoko Higuchi Masatoshi Minamisawa Hiroshi Kitabayashi Koichiro Kuwahara Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
description	Abstract The Glasgow Prognostic Score (GPS) has been established as a useful resource to evaluate inflammation and malnutrition and predict prognosis in several cancers. However, its prognostic significance in patients with heart failure (HF) is not well established. To investigate the association between the GPS and mortality in patients with HF, we assessed 870 patients who were 20 years old and more and had been admitted for acute decompensated HF. The GPS ranged from 0 to 2 points as previously reported. Over the 18-month follow-up (follow-up rate, 83.9%), 143 patients died. Increasing GPS was associated with higher HF severity assessed by New York Heart Association functional class and B-type natriuretic peptide (BNP) levels. Kaplan–Meier analysis showed significant associations for mortality and increased GPS. In multivariate analysis, compared to the GPS 0 group, the GPS 2 group was associated with high mortality (hazard ratio 2.92, 95% confidence interval 1.77–4.81, p < 0.001) after adjustment for age, sex, blood pressure, HF history, HF severity, hemoglobin, renal function, sodium, BNP, left ventricular ejection fraction, and anti-HF medications. In conclusion, high GPS was significantly associated with worse prognosis in patients with HF. Inflammation-based assessment by the GPS may enable simple evaluation of HF severity and prognosis.
format	article
author	Tadashi Itagaki Hirohiko Motoki Kyuhachi Otagiri Keisuke Machida Takahiro Takeuchi Masafumi Kanai Kazuhiro Kimura Satoko Higuchi Masatoshi Minamisawa Hiroshi Kitabayashi Koichiro Kuwahara
author_facet	Tadashi Itagaki Hirohiko Motoki Kyuhachi Otagiri Keisuke Machida Takahiro Takeuchi Masafumi Kanai Kazuhiro Kimura Satoko Higuchi Masatoshi Minamisawa Hiroshi Kitabayashi Koichiro Kuwahara
author_sort	Tadashi Itagaki
title	Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
title_short	Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
title_full	Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
title_fullStr	Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
title_full_unstemmed	Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
title_sort	inflammation-based assessment for the risk stratification of mortality in patients with heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9872d6425274422a8045d7d8f238906
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Inflammation-based assessment for the risk stratification of mortality in patients with heart failure

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