Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study

Abstract Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal pla...

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Autores principales:	Ai-Ru Chia, Jamie V. de Seymour, Gerard Wong, Karolina Sulek, Ting-Li Han, Elizabeth J. McKenzie, Izzuddin M. Aris, Keith M. Godfrey, Fabian Yap, Kok Hian Tan, Lynette Pei-Chi Shek, Yung Seng Lee, Michael S. Kramer, Neerja Karnani, Mary Foong-Fong Chong, Philip N. Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9876ba0d9bd4ebbb00bf791f33e1ced
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spelling	oai:doaj.org-article:e9876ba0d9bd4ebbb00bf791f33e1ced2021-12-02T17:52:23ZMaternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study10.1038/s41598-020-66026-52045-2322https://doaj.org/article/e9876ba0d9bd4ebbb00bf791f33e1ced2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66026-5https://doaj.org/toc/2045-2322Abstract Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal plasma metabolites associated with infant adiposity and other birth outcomes and (ii) investigate the maternal characteristics associated with those metabolites. In 940 mother-offspring pairs, we performed gas chromatography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26–28 weeks of gestation. At birth, neonatal triceps and subscapular skinfold thicknesses were measured by trained research personnel, while weight and length measures were abstracted from delivery records. Gestational age was estimated from first-trimester dating ultrasound. Associations were assessed by multivariable linear regression, with p-values corrected using the Benjamini-Hochberg approach. At a false discovery rate of 5%, we observed associations between 28 metabolites and neonatal sum of skinfold thicknesses (13 amino acid-related, 4 non-esterified fatty acids, 6 xenobiotics, and 5 unknown compounds). Few associations were observed with gestational duration, birth weight, or birth length. Maternal ethnicity, pre-pregnancy BMI, and diet quality during pregnancy had the strongest associations with the specific metabolome related to infant adiposity. Further studies are warranted to replicate our findings and to understand the underlying mechanisms.Ai-Ru ChiaJamie V. de SeymourGerard WongKarolina SulekTing-Li HanElizabeth J. McKenzieIzzuddin M. ArisKeith M. GodfreyFabian YapKok Hian TanLynette Pei-Chi ShekYung Seng LeeMichael S. KramerNeerja KarnaniMary Foong-Fong ChongPhilip N. BakerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ai-Ru Chia Jamie V. de Seymour Gerard Wong Karolina Sulek Ting-Li Han Elizabeth J. McKenzie Izzuddin M. Aris Keith M. Godfrey Fabian Yap Kok Hian Tan Lynette Pei-Chi Shek Yung Seng Lee Michael S. Kramer Neerja Karnani Mary Foong-Fong Chong Philip N. Baker Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
description	Abstract Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal plasma metabolites associated with infant adiposity and other birth outcomes and (ii) investigate the maternal characteristics associated with those metabolites. In 940 mother-offspring pairs, we performed gas chromatography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26–28 weeks of gestation. At birth, neonatal triceps and subscapular skinfold thicknesses were measured by trained research personnel, while weight and length measures were abstracted from delivery records. Gestational age was estimated from first-trimester dating ultrasound. Associations were assessed by multivariable linear regression, with p-values corrected using the Benjamini-Hochberg approach. At a false discovery rate of 5%, we observed associations between 28 metabolites and neonatal sum of skinfold thicknesses (13 amino acid-related, 4 non-esterified fatty acids, 6 xenobiotics, and 5 unknown compounds). Few associations were observed with gestational duration, birth weight, or birth length. Maternal ethnicity, pre-pregnancy BMI, and diet quality during pregnancy had the strongest associations with the specific metabolome related to infant adiposity. Further studies are warranted to replicate our findings and to understand the underlying mechanisms.
format	article
author	Ai-Ru Chia Jamie V. de Seymour Gerard Wong Karolina Sulek Ting-Li Han Elizabeth J. McKenzie Izzuddin M. Aris Keith M. Godfrey Fabian Yap Kok Hian Tan Lynette Pei-Chi Shek Yung Seng Lee Michael S. Kramer Neerja Karnani Mary Foong-Fong Chong Philip N. Baker
author_facet	Ai-Ru Chia Jamie V. de Seymour Gerard Wong Karolina Sulek Ting-Li Han Elizabeth J. McKenzie Izzuddin M. Aris Keith M. Godfrey Fabian Yap Kok Hian Tan Lynette Pei-Chi Shek Yung Seng Lee Michael S. Kramer Neerja Karnani Mary Foong-Fong Chong Philip N. Baker
author_sort	Ai-Ru Chia
title	Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
title_short	Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
title_full	Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
title_fullStr	Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
title_full_unstemmed	Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
title_sort	maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: the gusto study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e9876ba0d9bd4ebbb00bf791f33e1ced
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Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study

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