A non-conserved amino acid variant regulates differential signalling between human and mouse CD28
CD28 transmits co-stimulatory signals for the activation of both mouse and human T cells, but in vivo hyperactivation of CD28 has opposite effects on system immunity. Here, the authors show that a single amino acid difference between mouse and human CD28 dictates this function distinction via differ...
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Nature Portfolio
2018
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oai:doaj.org-article:e98ff31ccbfc47539c572574b4d9cb312021-12-02T15:34:03ZA non-conserved amino acid variant regulates differential signalling between human and mouse CD2810.1038/s41467-018-03385-82041-1723https://doaj.org/article/e98ff31ccbfc47539c572574b4d9cb312018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03385-8https://doaj.org/toc/2041-1723CD28 transmits co-stimulatory signals for the activation of both mouse and human T cells, but in vivo hyperactivation of CD28 has opposite effects on system immunity. Here, the authors show that a single amino acid difference between mouse and human CD28 dictates this function distinction via differential recruitment of Nck.Nicla PorcielloPaola GrazioliAntonio F. CampeseMartina KunklSilvana CaristiMarta MastrogiovanniMichela MuscoliniFrancesca SpadaroCédric FavreJacques A. NunèsAldo BorrotoBalbino AlarconIsabella ScrepantiLoretta TuostoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nicla Porciello Paola Grazioli Antonio F. Campese Martina Kunkl Silvana Caristi Marta Mastrogiovanni Michela Muscolini Francesca Spadaro Cédric Favre Jacques A. Nunès Aldo Borroto Balbino Alarcon Isabella Screpanti Loretta Tuosto A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 |
| description |
CD28 transmits co-stimulatory signals for the activation of both mouse and human T cells, but in vivo hyperactivation of CD28 has opposite effects on system immunity. Here, the authors show that a single amino acid difference between mouse and human CD28 dictates this function distinction via differential recruitment of Nck. |
| format |
article |
| author |
Nicla Porciello Paola Grazioli Antonio F. Campese Martina Kunkl Silvana Caristi Marta Mastrogiovanni Michela Muscolini Francesca Spadaro Cédric Favre Jacques A. Nunès Aldo Borroto Balbino Alarcon Isabella Screpanti Loretta Tuosto |
| author_facet |
Nicla Porciello Paola Grazioli Antonio F. Campese Martina Kunkl Silvana Caristi Marta Mastrogiovanni Michela Muscolini Francesca Spadaro Cédric Favre Jacques A. Nunès Aldo Borroto Balbino Alarcon Isabella Screpanti Loretta Tuosto |
| author_sort |
Nicla Porciello |
| title |
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 |
| title_short |
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 |
| title_full |
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 |
| title_fullStr |
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 |
| title_full_unstemmed |
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 |
| title_sort |
non-conserved amino acid variant regulates differential signalling between human and mouse cd28 |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e98ff31ccbfc47539c572574b4d9cb31 |
| work_keys_str_mv |
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