Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study

Qing Sun,1,2 Liang Tang,2 Qiurong Zeng,2 Mingjun Gu2 1Department of Clinical Nutrition, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People’s Republic of China; 2Department of Endocrinology, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People’s Rep...

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Autores principales:	Sun Q, Tang L, Zeng Q, Gu M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic retinopathy generalized additive model glucose blood pressure Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e9902a67aabd49a5bea5a6819dde61b5
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spelling	oai:doaj.org-article:e9902a67aabd49a5bea5a6819dde61b52021-12-02T18:31:08ZAssessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study1178-7007https://doaj.org/article/e9902a67aabd49a5bea5a6819dde61b52021-04-01T00:00:00Zhttps://www.dovepress.com/assessment-for-the-correlation-between-diabetic-retinopathy-and-metabo-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Qing Sun,1,2 Liang Tang,2 Qiurong Zeng,2 Mingjun Gu2 1Department of Clinical Nutrition, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People’s Republic of China; 2Department of Endocrinology, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People’s Republic of ChinaCorrespondence: Mingjun GuDepartment of Endocrinology, Fuling Center Hospital of Chongqing City, No. 2 Fuling District, Gaosuntang Road, Chongqing, 408000, People’s Republic of ChinaTel +86 13996860971Email mingjungudr@163.comPurpose: In this study, we explored the correlation between diabetic retinopathy (DR) and metabolic syndrome (MetS) among diabetes mellitus (DM) patients.Methods: Logistic regression analysis was utilized to test the effects of MetS and its indicators on the incidence of DR and vision-related functional burden. The spline smoothing functions of continuous indicators of MetS were used to establish the logistic generalized additive model (GAM). The effective degree of freedom (EDF) =1 was served as a sign of linear relationship. EDF> 1 was a sign of a more complex association between MetS and DR.Results: The proportion of difficulties of looking for objects on the crowded shelves in the DR group was higher than that in the non-DR group (19.40 vs 12.10, P< 0.05). Elevated fasting glucose (Glu) and blood pressure levels were related to the vision-related functional burden. The risk of DR development increased by 6% [95% confidence interval (CI): 1.03– 1.09, P< 0.001] and 1% (95% CI: 1.01– 1.02, P=0.004) per 1 unit increase in Glu and systolic blood pressure (SBP) of DM patients, respectively. In the univariate GAM, Glu had a linear effect on DR (EDF=1, P< 0.001) with a positive correlation after controlling SBP. And there was a nonlinear correlation between SBP and DR after controlling Glu (EDF=2.44, P=0.024).Conclusion: Both Glu and blood pressure were associated with the occurrence of DR and vision-related functional burden. Controlling the levels of Glu and blood pressure may reduce the risk of DR and vision loss among DM patients.Keywords: diabetic retinopathy, generalized additive model, glucose, blood pressureSun QTang LZeng QGu MDove Medical Pressarticlediabetic retinopathygeneralized additive modelglucoseblood pressureSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1773-1781 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic retinopathy generalized additive model glucose blood pressure Specialties of internal medicine RC581-951
spellingShingle	diabetic retinopathy generalized additive model glucose blood pressure Specialties of internal medicine RC581-951 Sun Q Tang L Zeng Q Gu M Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study
description	Qing Sun,1,2 Liang Tang,2 Qiurong Zeng,2 Mingjun Gu2 1Department of Clinical Nutrition, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People’s Republic of China; 2Department of Endocrinology, Fuling Center Hospital of Chongqing City, Chongqing, 408000, People’s Republic of ChinaCorrespondence: Mingjun GuDepartment of Endocrinology, Fuling Center Hospital of Chongqing City, No. 2 Fuling District, Gaosuntang Road, Chongqing, 408000, People’s Republic of ChinaTel +86 13996860971Email mingjungudr@163.comPurpose: In this study, we explored the correlation between diabetic retinopathy (DR) and metabolic syndrome (MetS) among diabetes mellitus (DM) patients.Methods: Logistic regression analysis was utilized to test the effects of MetS and its indicators on the incidence of DR and vision-related functional burden. The spline smoothing functions of continuous indicators of MetS were used to establish the logistic generalized additive model (GAM). The effective degree of freedom (EDF) =1 was served as a sign of linear relationship. EDF> 1 was a sign of a more complex association between MetS and DR.Results: The proportion of difficulties of looking for objects on the crowded shelves in the DR group was higher than that in the non-DR group (19.40 vs 12.10, P< 0.05). Elevated fasting glucose (Glu) and blood pressure levels were related to the vision-related functional burden. The risk of DR development increased by 6% [95% confidence interval (CI): 1.03– 1.09, P< 0.001] and 1% (95% CI: 1.01– 1.02, P=0.004) per 1 unit increase in Glu and systolic blood pressure (SBP) of DM patients, respectively. In the univariate GAM, Glu had a linear effect on DR (EDF=1, P< 0.001) with a positive correlation after controlling SBP. And there was a nonlinear correlation between SBP and DR after controlling Glu (EDF=2.44, P=0.024).Conclusion: Both Glu and blood pressure were associated with the occurrence of DR and vision-related functional burden. Controlling the levels of Glu and blood pressure may reduce the risk of DR and vision loss among DM patients.Keywords: diabetic retinopathy, generalized additive model, glucose, blood pressure
format	article
author	Sun Q Tang L Zeng Q Gu M
author_facet	Sun Q Tang L Zeng Q Gu M
author_sort	Sun Q
title	Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study
title_short	Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study
title_full	Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study
title_fullStr	Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study
title_full_unstemmed	Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study
title_sort	assessment for the correlation between diabetic retinopathy and metabolic syndrome: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e9902a67aabd49a5bea5a6819dde61b5
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Assessment for the Correlation Between Diabetic Retinopathy and Metabolic Syndrome: A Cross-Sectional Study

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