Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression

Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ludmila Alekseeva, Nadezhda Mironova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	circulating cell-free DNA neutrophil extracellular traps (NETs) tumor and metastasis development DNases Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e9962a930f0546f3a17937210578e9fe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9962a930f0546f3a17937210578e9fe
record_format	dspace
spelling	oai:doaj.org-article:e9962a930f0546f3a17937210578e9fe2021-11-25T17:54:40ZRole of Cell-Free DNA and Deoxyribonucleases in Tumor Progression10.3390/ijms2222122461422-00671661-6596https://doaj.org/article/e9962a930f0546f3a17937210578e9fe2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12246https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vulnerable organs, transforming them and forming metastatic nodes. Another source of cfDNA is immune cells, including neutrophils that generate neutrophil extracellular traps (NETs). Despite the potential eliminative effect of NETs on tumors, in some cases, their excessive generation provokes tumor growth as well as invasion. Considering both possible pathological contributions of cfDNA, as an agent of oncotransformation and the main component of NETs, the study of deoxyribonucleases (DNases) as anticancer and antimetastatic agents is important and promising. This review considers the pathological role of cfDNA in cancer development and the role of DNases as agents to prevent and/or prohibit tumor progression and the development of metastases.Ludmila AlekseevaNadezhda MironovaMDPI AGarticlecirculating cell-free DNAneutrophil extracellular traps (NETs)tumor and metastasis developmentDNasesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12246, p 12246 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circulating cell-free DNA neutrophil extracellular traps (NETs) tumor and metastasis development DNases Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	circulating cell-free DNA neutrophil extracellular traps (NETs) tumor and metastasis development DNases Biology (General) QH301-705.5 Chemistry QD1-999 Ludmila Alekseeva Nadezhda Mironova Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
description	Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile. Moreover, tumor-derived cfDNA can act like oncoviruses, entering the cells of vulnerable organs, transforming them and forming metastatic nodes. Another source of cfDNA is immune cells, including neutrophils that generate neutrophil extracellular traps (NETs). Despite the potential eliminative effect of NETs on tumors, in some cases, their excessive generation provokes tumor growth as well as invasion. Considering both possible pathological contributions of cfDNA, as an agent of oncotransformation and the main component of NETs, the study of deoxyribonucleases (DNases) as anticancer and antimetastatic agents is important and promising. This review considers the pathological role of cfDNA in cancer development and the role of DNases as agents to prevent and/or prohibit tumor progression and the development of metastases.
format	article
author	Ludmila Alekseeva Nadezhda Mironova
author_facet	Ludmila Alekseeva Nadezhda Mironova
author_sort	Ludmila Alekseeva
title	Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
title_short	Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
title_full	Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
title_fullStr	Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
title_full_unstemmed	Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression
title_sort	role of cell-free dna and deoxyribonucleases in tumor progression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e9962a930f0546f3a17937210578e9fe
work_keys_str_mv	AT ludmilaalekseeva roleofcellfreednaanddeoxyribonucleasesintumorprogression AT nadezhdamironova roleofcellfreednaanddeoxyribonucleasesintumorprogression
_version_	1718411896180178944

Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression

Ejemplares similares