Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria

Insertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over 50,000 generations.

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Main Authors:	Jessika Consuegra, Joël Gaffé, Richard E. Lenski, Thomas Hindré, Jeffrey E. Barrick, Olivier Tenaillon, Dominique Schneider
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/e996c6b3661a4328bd3da865b5d3e48a
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spelling	oai:doaj.org-article:e996c6b3661a4328bd3da865b5d3e48a2021-12-02T14:26:44ZInsertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria10.1038/s41467-021-21210-72041-1723https://doaj.org/article/e996c6b3661a4328bd3da865b5d3e48a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21210-7https://doaj.org/toc/2041-1723Insertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over 50,000 generations.Jessika ConsuegraJoël GafféRichard E. LenskiThomas HindréJeffrey E. BarrickOlivier TenaillonDominique SchneiderNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessika Consuegra Joël Gaffé Richard E. Lenski Thomas Hindré Jeffrey E. Barrick Olivier Tenaillon Dominique Schneider Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
description	Insertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over 50,000 generations.
format	article
author	Jessika Consuegra Joël Gaffé Richard E. Lenski Thomas Hindré Jeffrey E. Barrick Olivier Tenaillon Dominique Schneider
author_facet	Jessika Consuegra Joël Gaffé Richard E. Lenski Thomas Hindré Jeffrey E. Barrick Olivier Tenaillon Dominique Schneider
author_sort	Jessika Consuegra
title	Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_short	Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_full	Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_fullStr	Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_full_unstemmed	Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_sort	insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e996c6b3661a4328bd3da865b5d3e48a
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Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria

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