LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional receptors and amplify mitophagy.

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Autores principales:	Benjamin Scott Padman, Thanh Ngoc Nguyen, Louise Uoselis, Marvin Skulsuppaisarn, Lan K. Nguyen, Michael Lazarou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e997010551564f7caf61ed3ea0695365
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spelling	oai:doaj.org-article:e997010551564f7caf61ed3ea06953652021-12-02T16:57:51ZLC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy10.1038/s41467-019-08335-62041-1723https://doaj.org/article/e997010551564f7caf61ed3ea06953652019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08335-6https://doaj.org/toc/2041-1723Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional receptors and amplify mitophagy.Benjamin Scott PadmanThanh Ngoc NguyenLouise UoselisMarvin SkulsuppaisarnLan K. NguyenMichael LazarouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin Scott Padman Thanh Ngoc Nguyen Louise Uoselis Marvin Skulsuppaisarn Lan K. Nguyen Michael Lazarou LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
description	Selective autophagy receptors are thought to selectively recruit Atg8 positive membranes to cargo via their LIR motif. Here, the authors show the LIR motifs in OPTN and NDP52 are dispensable for selectivity, functioning instead to recruit additional receptors and amplify mitophagy.
format	article
author	Benjamin Scott Padman Thanh Ngoc Nguyen Louise Uoselis Marvin Skulsuppaisarn Lan K. Nguyen Michael Lazarou
author_facet	Benjamin Scott Padman Thanh Ngoc Nguyen Louise Uoselis Marvin Skulsuppaisarn Lan K. Nguyen Michael Lazarou
author_sort	Benjamin Scott Padman
title	LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
title_short	LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
title_full	LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
title_fullStr	LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
title_full_unstemmed	LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy
title_sort	lc3/gabaraps drive ubiquitin-independent recruitment of optineurin and ndp52 to amplify mitophagy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e997010551564f7caf61ed3ea0695365
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LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

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