In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

Priyaveena Puvanakrishnan1, Jaesook Park1, Deyali Chatterjee2, Sunil Krishnan2, James W Tunnell11Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA; 2The UT MD Anderson Cancer Center, Houston, TX, USAAbstract: Gold nanoparticles (GNPs) have gained significant in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Puvanakrishnan P, Park J, Chatterjee D, Krishnan S, Tunnell JW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e998582e9f9f405880339672fa38f76e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e998582e9f9f405880339672fa38f76e
record_format	dspace
spelling	oai:doaj.org-article:e998582e9f9f405880339672fa38f76e2021-12-02T04:46:24ZIn vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy1176-91141178-2013https://doaj.org/article/e998582e9f9f405880339672fa38f76e2012-03-01T00:00:00Zhttp://www.dovepress.com/in-vivo-tumor-targeting-of-gold-nanoparticles-effect-of-particle-type--a9423https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Priyaveena Puvanakrishnan1, Jaesook Park1, Deyali Chatterjee2, Sunil Krishnan2, James W Tunnell11Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA; 2The UT MD Anderson Cancer Center, Houston, TX, USAAbstract: Gold nanoparticles (GNPs) have gained significant interest as nanovectors for combined imaging and photothermal therapy of tumors. Delivered systemically, GNPs preferentially accumulate at the tumor site via the enhanced permeability and retention effect, and when irradiated with near infrared light, produce sufficient heat to treat tumor tissue. The efficacy of this process strongly depends on the targeting ability of the GNPs, which is a function of the particle&rsquo;s geometric properties (eg, size) and dosing strategy (eg, number and amount of injections). The purpose of this study was to investigate the effect of GNP type and dosing strategy on in vivo tumor targeting. Specifically, we investigated the in vivo tumor-targeting efficiency of pegylated gold nanoshells (GNSs) and gold nanorods (GNRs) for single and multiple dosing. We used Swiss nu/nu mice with a subcutaneous tumor xenograft model that received intravenous administration for a single and multiple doses of GNS and GNR. We performed neutron activation analysis to quantify the gold present in the tumor and liver. We performed histology to determine if there was acute toxicity as a result of multiple dosing. Neutron activation analysis results showed that the smaller GNRs accumulated in higher concentrations in the tumor compared to the larger GNSs. We observed a significant increase in GNS and GNR accumulation in the liver for higher doses. However, multiple doses increased targeting efficiency with minimal effect beyond three doses of GNPs. These results suggest a significant effect of particle type and multiple doses on increasing particle accumulation and on tumor targeting ability.Keywords: gold nanorods, gold nanoshells, tumor targeting, multiple dosingPuvanakrishnan PPark JChatterjee DKrishnan STunnell JWDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 1251-1258 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Puvanakrishnan P Park J Chatterjee D Krishnan S Tunnell JW In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
description	Priyaveena Puvanakrishnan1, Jaesook Park1, Deyali Chatterjee2, Sunil Krishnan2, James W Tunnell11Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA; 2The UT MD Anderson Cancer Center, Houston, TX, USAAbstract: Gold nanoparticles (GNPs) have gained significant interest as nanovectors for combined imaging and photothermal therapy of tumors. Delivered systemically, GNPs preferentially accumulate at the tumor site via the enhanced permeability and retention effect, and when irradiated with near infrared light, produce sufficient heat to treat tumor tissue. The efficacy of this process strongly depends on the targeting ability of the GNPs, which is a function of the particle&rsquo;s geometric properties (eg, size) and dosing strategy (eg, number and amount of injections). The purpose of this study was to investigate the effect of GNP type and dosing strategy on in vivo tumor targeting. Specifically, we investigated the in vivo tumor-targeting efficiency of pegylated gold nanoshells (GNSs) and gold nanorods (GNRs) for single and multiple dosing. We used Swiss nu/nu mice with a subcutaneous tumor xenograft model that received intravenous administration for a single and multiple doses of GNS and GNR. We performed neutron activation analysis to quantify the gold present in the tumor and liver. We performed histology to determine if there was acute toxicity as a result of multiple dosing. Neutron activation analysis results showed that the smaller GNRs accumulated in higher concentrations in the tumor compared to the larger GNSs. We observed a significant increase in GNS and GNR accumulation in the liver for higher doses. However, multiple doses increased targeting efficiency with minimal effect beyond three doses of GNPs. These results suggest a significant effect of particle type and multiple doses on increasing particle accumulation and on tumor targeting ability.Keywords: gold nanorods, gold nanoshells, tumor targeting, multiple dosing
format	article
author	Puvanakrishnan P Park J Chatterjee D Krishnan S Tunnell JW
author_facet	Puvanakrishnan P Park J Chatterjee D Krishnan S Tunnell JW
author_sort	Puvanakrishnan P
title	In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
title_short	In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
title_full	In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
title_fullStr	In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
title_full_unstemmed	In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
title_sort	in vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/e998582e9f9f405880339672fa38f76e
work_keys_str_mv	AT puvanakrishnanp invivotumortargetingofgoldnanoparticleseffectofparticletypeanddosingstrategy AT parkj invivotumortargetingofgoldnanoparticleseffectofparticletypeanddosingstrategy AT chatterjeed invivotumortargetingofgoldnanoparticleseffectofparticletypeanddosingstrategy AT krishnans invivotumortargetingofgoldnanoparticleseffectofparticletypeanddosingstrategy AT tunnelljw invivotumortargetingofgoldnanoparticleseffectofparticletypeanddosingstrategy
_version_	1718401071764733952

In vivo tumor targeting of gold nanoparticles: effect of particle type and dosing strategy

Ejemplares similares