Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review

Erick Damian Castañeda-Reyes,1,2 Maria de Jesús Perea-Flores,3 Gloria Davila-Ortiz,1 Youngsoo Lee,2 Elvira Gonzalez de Mejia2 1Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacio...

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Autores principales:	Castañeda-Reyes ED, Perea-Flores MJ, Davila-Ortiz G, Lee Y, de Mejia EG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	edge activators encapsulation inflammation melanoma nanotransporters skin delivery ultadeformable liposomes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/e999f83d40344481ae537711f75c8b7b
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spelling	oai:doaj.org-article:e999f83d40344481ae537711f75c8b7b2021-12-02T12:46:23ZDevelopment, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review1178-2013https://doaj.org/article/e999f83d40344481ae537711f75c8b7b2020-10-01T00:00:00Zhttps://www.dovepress.com/development-characterization-and-use-of-liposomes-as-amphipathic-trans-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Erick Damian Castañeda-Reyes,1,2 Maria de Jesús Perea-Flores,3 Gloria Davila-Ortiz,1 Youngsoo Lee,2 Elvira Gonzalez de Mejia2 1Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Unidad Profesional Adolfo Lopez Mateos, Ciudad De México, 07738, México; 2Department of Food Science and Human Nutrition, University of Illinois at Urbana–Champaign, Champaign, IL, USA; 3Centro de Nanociencias y Micro y Nanotecnologías, Instituto Politécnico Nacional (IPN), Unidad Profesional Adolfo López Mateos, Ciudad De México 07738, MéxicoCorrespondence: Elvira Gonzalez de MejiaDepartment of Food Science and Human Nutrition, University of Illinois at Urbana–Champaign, 228 ERML, 1201 West Gregory Dr, Urbana, IL 61801, USATel +1 217 244-3196Email edemejia@illinois.eduAbstract: The skin is the largest organ in the human body, providing a barrier to the external environment. It is composed of three layers: epidermis, dermis and hypodermis. The most external epidermis is exposed to stress factors that may lead to skin conditions such as photo-aging and skin cancer. Some treatments for skin disease utilize the incorporation of drugs or bioactive compounds into nanocarriers known as liposomes. Liposomes are membranes whose sizes range from nano to micrometers and are composed mostly of phospholipids and cholesterol, forming similar structures to cell membranes. Thus, skin treatments with liposomes have lower toxicity in comparison to traditional treatment routes such as parenteral and oral. Furthermore, addition of edge activators to the liposomes decreases the rigidity of the bilayer structure making it deformable, thereby improving skin permeability. Liposomes are composed of an aqueous core and a lipidic bilayer, which confers their amphiphilic property. Thus, they can carry hydrophobic and hydrophilic compounds, even simultaneously. Current applications of these nanocarriers are mainly in the cosmetic and pharmaceutic industries. Nevertheless, new research has revealed promising results regarding the effectiveness of liposomes for transporting bioactive compounds through the skin. Liposomes have been well studied; however, additional research is needed on the efficacy of liposomes loaded with bioactive peptides for skin delivery. The objective of this review is to provide an up-to-date description of existing techniques for the development of liposomes and their use as transporters of bioactive compounds in skin conditions such as melanoma and skin inflammation. Furthermore, to gain an understanding of the behavior of liposomes during the process of skin delivery of bioactive compounds into skin cells.Keywords: edge activators, encapsulation, inflammation, melanoma, nanotransporters, skin delivery, ultadeformable liposomesCastañeda-Reyes EDPerea-Flores MJDavila-Ortiz GLee Yde Mejia EGDove Medical Pressarticleedge activatorsencapsulationinflammationmelanomananotransportersskin deliveryultadeformable liposomesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 7627-7650 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	edge activators encapsulation inflammation melanoma nanotransporters skin delivery ultadeformable liposomes Medicine (General) R5-920
spellingShingle	edge activators encapsulation inflammation melanoma nanotransporters skin delivery ultadeformable liposomes Medicine (General) R5-920 Castañeda-Reyes ED Perea-Flores MJ Davila-Ortiz G Lee Y de Mejia EG Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review
description	Erick Damian Castañeda-Reyes,1,2 Maria de Jesús Perea-Flores,3 Gloria Davila-Ortiz,1 Youngsoo Lee,2 Elvira Gonzalez de Mejia2 1Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional (IPN), Unidad Profesional Adolfo Lopez Mateos, Ciudad De México, 07738, México; 2Department of Food Science and Human Nutrition, University of Illinois at Urbana–Champaign, Champaign, IL, USA; 3Centro de Nanociencias y Micro y Nanotecnologías, Instituto Politécnico Nacional (IPN), Unidad Profesional Adolfo López Mateos, Ciudad De México 07738, MéxicoCorrespondence: Elvira Gonzalez de MejiaDepartment of Food Science and Human Nutrition, University of Illinois at Urbana–Champaign, 228 ERML, 1201 West Gregory Dr, Urbana, IL 61801, USATel +1 217 244-3196Email edemejia@illinois.eduAbstract: The skin is the largest organ in the human body, providing a barrier to the external environment. It is composed of three layers: epidermis, dermis and hypodermis. The most external epidermis is exposed to stress factors that may lead to skin conditions such as photo-aging and skin cancer. Some treatments for skin disease utilize the incorporation of drugs or bioactive compounds into nanocarriers known as liposomes. Liposomes are membranes whose sizes range from nano to micrometers and are composed mostly of phospholipids and cholesterol, forming similar structures to cell membranes. Thus, skin treatments with liposomes have lower toxicity in comparison to traditional treatment routes such as parenteral and oral. Furthermore, addition of edge activators to the liposomes decreases the rigidity of the bilayer structure making it deformable, thereby improving skin permeability. Liposomes are composed of an aqueous core and a lipidic bilayer, which confers their amphiphilic property. Thus, they can carry hydrophobic and hydrophilic compounds, even simultaneously. Current applications of these nanocarriers are mainly in the cosmetic and pharmaceutic industries. Nevertheless, new research has revealed promising results regarding the effectiveness of liposomes for transporting bioactive compounds through the skin. Liposomes have been well studied; however, additional research is needed on the efficacy of liposomes loaded with bioactive peptides for skin delivery. The objective of this review is to provide an up-to-date description of existing techniques for the development of liposomes and their use as transporters of bioactive compounds in skin conditions such as melanoma and skin inflammation. Furthermore, to gain an understanding of the behavior of liposomes during the process of skin delivery of bioactive compounds into skin cells.Keywords: edge activators, encapsulation, inflammation, melanoma, nanotransporters, skin delivery, ultadeformable liposomes
format	article
author	Castañeda-Reyes ED Perea-Flores MJ Davila-Ortiz G Lee Y de Mejia EG
author_facet	Castañeda-Reyes ED Perea-Flores MJ Davila-Ortiz G Lee Y de Mejia EG
author_sort	Castañeda-Reyes ED
title	Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review
title_short	Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review
title_full	Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review
title_fullStr	Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review
title_full_unstemmed	Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review
title_sort	development, characterization and use of liposomes as amphipathic transporters of bioactive compounds for melanoma treatment and reduction of skin inflammation: a review
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e999f83d40344481ae537711f75c8b7b
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Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review

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