Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma

Glioblastoma (GBM) is the most common malignant tumor of the central nervous system with poor prognosis. Although the field of immunotherapy in glioma is developing rapidly, glioblastoma is still prone to recurrence under strong immune intervention. The major challenges in the process of immunothera...

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Autores principales:	Yan Li, Yiqi Ma, Zijun Wu, Ruoxi Xie, Fanxin Zeng, Huawei Cai, Su Lui, Bin Song, Lei Chen, Min Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	glioblastoma immunotherapy treatment response pseudoprogression tumor recurrence advanced imaging Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e99b2c58e79e464cb8394df395d9d8fc
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spelling	oai:doaj.org-article:e99b2c58e79e464cb8394df395d9d8fc2021-12-01T02:21:24ZAdvanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma1664-322410.3389/fimmu.2021.790674https://doaj.org/article/e99b2c58e79e464cb8394df395d9d8fc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.790674/fullhttps://doaj.org/toc/1664-3224Glioblastoma (GBM) is the most common malignant tumor of the central nervous system with poor prognosis. Although the field of immunotherapy in glioma is developing rapidly, glioblastoma is still prone to recurrence under strong immune intervention. The major challenges in the process of immunotherapy are evaluating the curative effect, accurately distinguishing between treatment-related reactions and tumor recurrence, and providing guidance for clinical decision-making. Since the conventional magnetic resonance imaging (MRI) is usually difficult to distinguish between pseudoprogression and the true tumor progression, many studies have used various advanced imaging techniques to evaluate treatment-related responses. Meanwhile, criteria for efficacy evaluation of immunotherapy are constantly updated and improved. A standard imaging scheme to evaluate immunotherapeutic response will benefit patients finally. This review mainly summarizes the application status and future trend of several advanced imaging techniques in evaluating the efficacy of GBM immunotherapy.Yan LiYiqi MaZijun WuRuoxi XieFanxin ZengHuawei CaiSu LuiBin SongLei ChenLei ChenMin WuMin WuFrontiers Media S.A.articleglioblastomaimmunotherapytreatment responsepseudoprogressiontumor recurrenceadvanced imagingImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioblastoma immunotherapy treatment response pseudoprogression tumor recurrence advanced imaging Immunologic diseases. Allergy RC581-607
spellingShingle	glioblastoma immunotherapy treatment response pseudoprogression tumor recurrence advanced imaging Immunologic diseases. Allergy RC581-607 Yan Li Yiqi Ma Zijun Wu Ruoxi Xie Fanxin Zeng Huawei Cai Su Lui Bin Song Lei Chen Lei Chen Min Wu Min Wu Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma
description	Glioblastoma (GBM) is the most common malignant tumor of the central nervous system with poor prognosis. Although the field of immunotherapy in glioma is developing rapidly, glioblastoma is still prone to recurrence under strong immune intervention. The major challenges in the process of immunotherapy are evaluating the curative effect, accurately distinguishing between treatment-related reactions and tumor recurrence, and providing guidance for clinical decision-making. Since the conventional magnetic resonance imaging (MRI) is usually difficult to distinguish between pseudoprogression and the true tumor progression, many studies have used various advanced imaging techniques to evaluate treatment-related responses. Meanwhile, criteria for efficacy evaluation of immunotherapy are constantly updated and improved. A standard imaging scheme to evaluate immunotherapeutic response will benefit patients finally. This review mainly summarizes the application status and future trend of several advanced imaging techniques in evaluating the efficacy of GBM immunotherapy.
format	article
author	Yan Li Yiqi Ma Zijun Wu Ruoxi Xie Fanxin Zeng Huawei Cai Su Lui Bin Song Lei Chen Lei Chen Min Wu Min Wu
author_facet	Yan Li Yiqi Ma Zijun Wu Ruoxi Xie Fanxin Zeng Huawei Cai Su Lui Bin Song Lei Chen Lei Chen Min Wu Min Wu
author_sort	Yan Li
title	Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma
title_short	Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma
title_full	Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma
title_fullStr	Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma
title_full_unstemmed	Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma
title_sort	advanced imaging techniques for differentiating pseudoprogression and tumor recurrence after immunotherapy for glioblastoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e99b2c58e79e464cb8394df395d9d8fc
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Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma

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