Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer
Dan Wang,1 Yuwen Zhang,1 Qi Guo2 1Department of Pathology, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China; 2Department of Orthopedics, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China Background: Facile synthesis and small size ther...
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Dove Medical Press
2018
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oai:doaj.org-article:e99c369e3dbf415895a4c83d79396b712021-12-02T04:01:30ZSub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer1178-2013https://doaj.org/article/e99c369e3dbf415895a4c83d79396b712018-11-01T00:00:00Zhttps://www.dovepress.com/sub-10-nm-cu5fes4-cube-for-magnetic-resonance-imaging-guided-photother-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Dan Wang,1 Yuwen Zhang,1 Qi Guo2 1Department of Pathology, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China; 2Department of Orthopedics, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. Purpose: A ternary compound (Cu5FeS4), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.Patients and methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out.Results: The Cu5FeS4 cube with good T1-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T1-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu5FeS4 cube. Under the guidance of the T1-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu5FeS4 cube and only the group combined intravenous administration of Cu5FeS4 cube and laser irradiation nearly cured the tumor after 14 days.Conclusion: Our study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents. Keywords: magnetic nanoparticle, imaging, theranostic, 4T1, ultra-smallWang DZhang YGuo QDove Medical PressarticleCu5FeS4 cubemagnetic resonance imagingphotothermal therapycancerultra-smallMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7987-7996 (2018) |
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Cu5FeS4 cube magnetic resonance imaging photothermal therapy cancer ultra-small Medicine (General) R5-920 |
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Cu5FeS4 cube magnetic resonance imaging photothermal therapy cancer ultra-small Medicine (General) R5-920 Wang D Zhang Y Guo Q Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| description |
Dan Wang,1 Yuwen Zhang,1 Qi Guo2 1Department of Pathology, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China; 2Department of Orthopedics, The First People’s Hospital of Shangqiu, Shangqiu, Henan 476000, China Background: Facile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment. Purpose: A ternary compound (Cu5FeS4), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.Patients and methods: Firstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out.Results: The Cu5FeS4 cube with good T1-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T1-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu5FeS4 cube. Under the guidance of the T1-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu5FeS4 cube and only the group combined intravenous administration of Cu5FeS4 cube and laser irradiation nearly cured the tumor after 14 days.Conclusion: Our study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents. Keywords: magnetic nanoparticle, imaging, theranostic, 4T1, ultra-small |
| format |
article |
| author |
Wang D Zhang Y Guo Q |
| author_facet |
Wang D Zhang Y Guo Q |
| author_sort |
Wang D |
| title |
Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| title_short |
Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| title_full |
Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| title_fullStr |
Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| title_full_unstemmed |
Sub-10 nm Cu5FeS4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| title_sort |
sub-10 nm cu5fes4 cube for magnetic resonance imaging-guided photothermal therapy of cancer |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/e99c369e3dbf415895a4c83d79396b71 |
| work_keys_str_mv |
AT wangd sub10nmcu5fes4cubeformagneticresonanceimagingguidedphotothermaltherapyofcancer AT zhangy sub10nmcu5fes4cubeformagneticresonanceimagingguidedphotothermaltherapyofcancer AT guoq sub10nmcu5fes4cubeformagneticresonanceimagingguidedphotothermaltherapyofcancer |
| _version_ |
1718401525526560768 |