Low testosterone and cardiometabolic risks in a real-world study of US male firefighters

Abstract Low serum total testosterone (TT) is associated with increased cardiovascular risk and metabolic derangements, with fatty liver (FL) emerging as an additional cardiometabolic threat. We investigated the associations between TT and cardiometabolic (CM) health in 298 US male firefighters. Cro...

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Autores principales:	Sushant M. Ranadive, Adriana Lofrano-Porto, Edgard M. K. V. K. Soares, Lauren Eagan, Luiz Guilherme Grossi Porto, Denise L. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e99f3d4c4aac4a638e59965f6857d133
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spelling	oai:doaj.org-article:e99f3d4c4aac4a638e59965f6857d1332021-12-02T18:34:13ZLow testosterone and cardiometabolic risks in a real-world study of US male firefighters10.1038/s41598-021-93603-z2045-2322https://doaj.org/article/e99f3d4c4aac4a638e59965f6857d1332021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93603-zhttps://doaj.org/toc/2045-2322Abstract Low serum total testosterone (TT) is associated with increased cardiovascular risk and metabolic derangements, with fatty liver (FL) emerging as an additional cardiometabolic threat. We investigated the associations between TT and cardiometabolic (CM) health in 298 US male firefighters. Cross-sectional data from occupational health examination were analyzed. TT was categorized as low (< 264 ng/dL), borderline (264–399 ng/dL), and reference (400–916 ng/dL). Conventional CM risk factors were compared among TT categories, and between firefighters with and without FL. 81% of firefighters were obese/overweight; almost 40% had FL. In the low-TT group, only 3.1% had normal BMI, while 78.1% had FL. The low-TT group had a worse CM profile, independently of age and BMI, and a fourfold higher adjusted odds of having FL. FL was associated with lower TT, regardless of age, BMI and HbA1c. Having a FL, HbA1c ≥ 5.7% or triglycerides ≥ 150 mg/dL increased the odds for low-TT by 4.1, 2.7 and 6.6 times, respectively. These real-world data reveal strong associations between low-TT and CM risk factors and support a call for action towards screening for low-TT and FL, regardless of age, BMI or dysmetabolic conditions in firefighters. Recognizing cardiometabolic risks in firefighters provides an opportunity to lessen cardiovascular diseases burden.Sushant M. RanadiveAdriana Lofrano-PortoEdgard M. K. V. K. SoaresLauren EaganLuiz Guilherme Grossi PortoDenise L. SmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sushant M. Ranadive Adriana Lofrano-Porto Edgard M. K. V. K. Soares Lauren Eagan Luiz Guilherme Grossi Porto Denise L. Smith Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
description	Abstract Low serum total testosterone (TT) is associated with increased cardiovascular risk and metabolic derangements, with fatty liver (FL) emerging as an additional cardiometabolic threat. We investigated the associations between TT and cardiometabolic (CM) health in 298 US male firefighters. Cross-sectional data from occupational health examination were analyzed. TT was categorized as low (< 264 ng/dL), borderline (264–399 ng/dL), and reference (400–916 ng/dL). Conventional CM risk factors were compared among TT categories, and between firefighters with and without FL. 81% of firefighters were obese/overweight; almost 40% had FL. In the low-TT group, only 3.1% had normal BMI, while 78.1% had FL. The low-TT group had a worse CM profile, independently of age and BMI, and a fourfold higher adjusted odds of having FL. FL was associated with lower TT, regardless of age, BMI and HbA1c. Having a FL, HbA1c ≥ 5.7% or triglycerides ≥ 150 mg/dL increased the odds for low-TT by 4.1, 2.7 and 6.6 times, respectively. These real-world data reveal strong associations between low-TT and CM risk factors and support a call for action towards screening for low-TT and FL, regardless of age, BMI or dysmetabolic conditions in firefighters. Recognizing cardiometabolic risks in firefighters provides an opportunity to lessen cardiovascular diseases burden.
format	article
author	Sushant M. Ranadive Adriana Lofrano-Porto Edgard M. K. V. K. Soares Lauren Eagan Luiz Guilherme Grossi Porto Denise L. Smith
author_facet	Sushant M. Ranadive Adriana Lofrano-Porto Edgard M. K. V. K. Soares Lauren Eagan Luiz Guilherme Grossi Porto Denise L. Smith
author_sort	Sushant M. Ranadive
title	Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
title_short	Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
title_full	Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
title_fullStr	Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
title_full_unstemmed	Low testosterone and cardiometabolic risks in a real-world study of US male firefighters
title_sort	low testosterone and cardiometabolic risks in a real-world study of us male firefighters
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e99f3d4c4aac4a638e59965f6857d133
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Low testosterone and cardiometabolic risks in a real-world study of US male firefighters

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