Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

Semaphorin-4A is a cell surface protein with known functions in neural development and immune regulation, but the mechanism for immune modulation is unclear. Here the authors show that ILT-4, previously found on myeloid cells, is the receptor of Semaphorin-4A on activate human CD4 T cells for mediat...

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Autores principales:	Ning Lu, Ying Li, Zhiqiang Zhang, Junji Xing, Ying Sun, Sheng Yao, Lieping Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9a07f42fb3e4178acef5acb85afb605
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spelling	oai:doaj.org-article:e9a07f42fb3e4178acef5acb85afb6052021-12-02T14:40:03ZHuman Semaphorin-4A drives Th2 responses by binding to receptor ILT-410.1038/s41467-018-03128-92041-1723https://doaj.org/article/e9a07f42fb3e4178acef5acb85afb6052018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03128-9https://doaj.org/toc/2041-1723Semaphorin-4A is a cell surface protein with known functions in neural development and immune regulation, but the mechanism for immune modulation is unclear. Here the authors show that ILT-4, previously found on myeloid cells, is the receptor of Semaphorin-4A on activate human CD4 T cells for mediating T cell co-stimulation.Ning LuYing LiZhiqiang ZhangJunji XingYing SunSheng YaoLieping ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ning Lu Ying Li Zhiqiang Zhang Junji Xing Ying Sun Sheng Yao Lieping Chen Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
description	Semaphorin-4A is a cell surface protein with known functions in neural development and immune regulation, but the mechanism for immune modulation is unclear. Here the authors show that ILT-4, previously found on myeloid cells, is the receptor of Semaphorin-4A on activate human CD4 T cells for mediating T cell co-stimulation.
format	article
author	Ning Lu Ying Li Zhiqiang Zhang Junji Xing Ying Sun Sheng Yao Lieping Chen
author_facet	Ning Lu Ying Li Zhiqiang Zhang Junji Xing Ying Sun Sheng Yao Lieping Chen
author_sort	Ning Lu
title	Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
title_short	Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
title_full	Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
title_fullStr	Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
title_full_unstemmed	Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
title_sort	human semaphorin-4a drives th2 responses by binding to receptor ilt-4
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e9a07f42fb3e4178acef5acb85afb605
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Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

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