An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

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Autores principales:	Yifeng Wang, Sumedha Gunewardena, Feng Li, David J. Matye, Cheng Chen, Xiaojuan Chao, Taeyoon Jung, Yuxia Zhang, Maciej Czerwiński, Hong-Min Ni, Wen-Xing Ding, Tiangang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce
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spelling	oai:doaj.org-article:e9a63e08c6d4478bbf30ac94313ec4ce2021-12-02T17:01:30ZAn FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis10.1038/s41467-020-17363-62041-1723https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17363-6https://doaj.org/toc/2041-1723TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.Yifeng WangSumedha GunewardenaFeng LiDavid J. MatyeCheng ChenXiaojuan ChaoTaeyoon JungYuxia ZhangMaciej CzerwińskiHong-Min NiWen-Xing DingTiangang LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
description	TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.
format	article
author	Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li
author_facet	Yifeng Wang Sumedha Gunewardena Feng Li David J. Matye Cheng Chen Xiaojuan Chao Taeyoon Jung Yuxia Zhang Maciej Czerwiński Hong-Min Ni Wen-Xing Ding Tiangang Li
author_sort	Yifeng Wang
title	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_short	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_full	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_fullStr	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_full_unstemmed	An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
title_sort	fgf15/19-tfeb regulatory loop controls hepatic cholesterol and bile acid homeostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce
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An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

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