An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

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Autores principales: Yifeng Wang, Sumedha Gunewardena, Feng Li, David J. Matye, Cheng Chen, Xiaojuan Chao, Taeyoon Jung, Yuxia Zhang, Maciej Czerwiński, Hong-Min Ni, Wen-Xing Ding, Tiangang Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce
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