An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.

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Bibliographic Details
Main Authors: Yifeng Wang, Sumedha Gunewardena, Feng Li, David J. Matye, Cheng Chen, Xiaojuan Chao, Taeyoon Jung, Yuxia Zhang, Maciej Czerwiński, Hong-Min Ni, Wen-Xing Ding, Tiangang Li
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce
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Internet

https://doaj.org/article/e9a63e08c6d4478bbf30ac94313ec4ce

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