Characterizing sympathetic neurovascular transduction in humans.

Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Can Ozan Tan, Renaud Tamisier, J W Hamner, J Andrew Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9a67dce3a3049c697b972562a51fa29
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9a67dce3a3049c697b972562a51fa29
record_format	dspace
spelling	oai:doaj.org-article:e9a67dce3a3049c697b972562a51fa292021-11-18T08:02:00ZCharacterizing sympathetic neurovascular transduction in humans.1932-620310.1371/journal.pone.0053769https://doaj.org/article/e9a67dce3a3049c697b972562a51fa292013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23326501/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuille's relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R(2) = 0.49±0.07) but lesser when incorporating beat-by-beat time lags (R(2) = 0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R(2)<0.33). In contrast, the Poiseuille relation reflected vascular responses more accurately (R(2) = 0.77±0.03, >0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R(2) = 0.37, p<0.05), but with a proportional bias. Thus, vascular resistance and conductance may not always be reliable surrogates for regional sympathetic neurovascular transduction, and assessment from a Poiseuille relation between pressure, sympathetic nerve activity, and flow may provide a better foundation to further explore differences in transduction in humans.Can Ozan TanRenaud TamisierJ W HamnerJ Andrew TaylorPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53769 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Can Ozan Tan Renaud Tamisier J W Hamner J Andrew Taylor Characterizing sympathetic neurovascular transduction in humans.
description	Despite its critical role for cardiovascular homeostasis in humans, only a few studies have directly probed the transduction of sympathetic nerve activity to regional vascular responses--sympathetic neurovascular transduction. Those that have variably relied on either vascular resistance or vascular conductance to quantify the responses. However, it remains unclear which approach would better reflect the physiology. We assessed the utility of both of these as well as an alternative approach in 21 healthy men. We recorded arterial pressure (Finapres), peroneal sympathetic nerve activity (microneurography), and popliteal blood flow (Doppler) during isometric handgrip exercise to fatigue. We quantified and compared transduction via the relation of sympathetic activity to resistance and to conductance and via an adaptation of Poiseuille's relation including pressure, sympathetic activity, and flow. The average relationship between sympathetic activity and resistance (or conductance) was good when assessed over 30-second averages (mean R(2) = 0.49±0.07) but lesser when incorporating beat-by-beat time lags (R(2) = 0.37±0.06). However, in a third of the subjects, these relations provided relatively weak estimates (R(2)<0.33). In contrast, the Poiseuille relation reflected vascular responses more accurately (R(2) = 0.77±0.03, >0.50 in 20 of 21 individuals), and provided reproducible estimates of transduction. The gain derived from the relation of resistance (but not conductance) was inversely related to transduction (R(2) = 0.37, p<0.05), but with a proportional bias. Thus, vascular resistance and conductance may not always be reliable surrogates for regional sympathetic neurovascular transduction, and assessment from a Poiseuille relation between pressure, sympathetic nerve activity, and flow may provide a better foundation to further explore differences in transduction in humans.
format	article
author	Can Ozan Tan Renaud Tamisier J W Hamner J Andrew Taylor
author_facet	Can Ozan Tan Renaud Tamisier J W Hamner J Andrew Taylor
author_sort	Can Ozan Tan
title	Characterizing sympathetic neurovascular transduction in humans.
title_short	Characterizing sympathetic neurovascular transduction in humans.
title_full	Characterizing sympathetic neurovascular transduction in humans.
title_fullStr	Characterizing sympathetic neurovascular transduction in humans.
title_full_unstemmed	Characterizing sympathetic neurovascular transduction in humans.
title_sort	characterizing sympathetic neurovascular transduction in humans.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e9a67dce3a3049c697b972562a51fa29
work_keys_str_mv	AT canozantan characterizingsympatheticneurovasculartransductioninhumans AT renaudtamisier characterizingsympatheticneurovasculartransductioninhumans AT jwhamner characterizingsympatheticneurovasculartransductioninhumans AT jandrewtaylor characterizingsympatheticneurovasculartransductioninhumans
_version_	1718422638731198464

Characterizing sympathetic neurovascular transduction in humans.

Ejemplares similares