Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how the large deletion CNV on chromosome 22q11.2 alters chromatin organization.

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Autores principales:	Xianglong Zhang, Ying Zhang, Xiaowei Zhu, Carolin Purmann, Michael S. Haney, Thomas Ward, Arineh Khechaduri, Jie Yao, Sherman M. Weissman, Alexander E. Urban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9aab59abbe142e29443cfd1acc2965a
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spelling	oai:doaj.org-article:e9aab59abbe142e29443cfd1acc2965a2021-12-02T17:32:03ZLocal and global chromatin interactions are altered by large genomic deletions associated with human brain development10.1038/s41467-018-07766-x2041-1723https://doaj.org/article/e9aab59abbe142e29443cfd1acc2965a2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07766-xhttps://doaj.org/toc/2041-1723Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how the large deletion CNV on chromosome 22q11.2 alters chromatin organization.Xianglong ZhangYing ZhangXiaowei ZhuCarolin PurmannMichael S. HaneyThomas WardArineh KhechaduriJie YaoSherman M. WeissmanAlexander E. UrbanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xianglong Zhang Ying Zhang Xiaowei Zhu Carolin Purmann Michael S. Haney Thomas Ward Arineh Khechaduri Jie Yao Sherman M. Weissman Alexander E. Urban Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
description	Copy number variants in the human genome (CNVs) are associated with neurodevelopmental and psychiatric disorders such as schizophrenia and autism. Here the authors investigate how the large deletion CNV on chromosome 22q11.2 alters chromatin organization.
format	article
author	Xianglong Zhang Ying Zhang Xiaowei Zhu Carolin Purmann Michael S. Haney Thomas Ward Arineh Khechaduri Jie Yao Sherman M. Weissman Alexander E. Urban
author_facet	Xianglong Zhang Ying Zhang Xiaowei Zhu Carolin Purmann Michael S. Haney Thomas Ward Arineh Khechaduri Jie Yao Sherman M. Weissman Alexander E. Urban
author_sort	Xianglong Zhang
title	Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
title_short	Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
title_full	Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
title_fullStr	Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
title_full_unstemmed	Local and global chromatin interactions are altered by large genomic deletions associated with human brain development
title_sort	local and global chromatin interactions are altered by large genomic deletions associated with human brain development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e9aab59abbe142e29443cfd1acc2965a
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Local and global chromatin interactions are altered by large genomic deletions associated with human brain development

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