Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation

Objective. To probe into the influence of dexmedetomidine (DEX) on diaphragm function and postoperative outcomes of mechanically ventilated patients in the intensive care unit (ICU). Methods. 84 patients with mechanical ventilation (MV) in the ICU of our hospital were selected as the research partic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chengda Zhao, Meihua Huang, Baiyun Wang, Huanhui Zhong, Wen Meng
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/e9abbfc950e3439caa005f18ddbf3501
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9abbfc950e3439caa005f18ddbf3501
record_format	dspace
spelling	oai:doaj.org-article:e9abbfc950e3439caa005f18ddbf35012021-11-08T02:36:40ZInfluence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation1741-428810.1155/2021/1990838https://doaj.org/article/e9abbfc950e3439caa005f18ddbf35012021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1990838https://doaj.org/toc/1741-4288Objective. To probe into the influence of dexmedetomidine (DEX) on diaphragm function and postoperative outcomes of mechanically ventilated patients in the intensive care unit (ICU). Methods. 84 patients with mechanical ventilation (MV) in the ICU of our hospital were selected as the research participants, including 38 patients in the control group (CG) sedated with midazolam (MZ) and 46 patients in the research group (RG) with DEX sedation. Ramsay sedation score, visual analogue scale (VAS), and restlessness score (RS) were used to evaluate their state before sedation (T0), as well as 2 h (T1), 6 h (T2), and 24 h (T3) after sedation, and the alterations of mean arterial pressure (MAP) and heart rate (HR) were recorded. Serum cortisol (Cor), adrenocorticotropic hormone (ACTH), superoxide dismutase (SOD), malondialdehyde (MDA), interleukin- (IL-) 1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured before and 24 h after sedation. The end-inspiratory diaphragm thickness (DTei) and end-expiratory diaphragm thickness (DTee) were measured within 2 h after the initiation of MV and 5 min after the spontaneous breathing test (SBT), and the diaphragm thickening fraction (DTF) was calculated. Finally, the ventilator weaning, MV time, and the incidence of adverse reactions (ADs) of the two groups were counted. Results. T0 and T3 witnessed no distinct difference in Ramsay, VAS, and RS scores between the two arms (P>0.05), but at T1 and T2, RG had better sedation state and lower VAS and RS scores than CG (P<0.05), with more stable vital signs (P<0.05). After sedation, the contents of oxidative stress and inflammatory factors in RG were lower, while DTee, DTei, and DTF were higher, versus CG (P<0.05). Moreover, RG presented higher success rate of first ventilator weaning, less MV time, and lower incidence of ADs than CG (P<0.05). Conclusions. DEX is effective in mechanically ventilated patients in the ICU, which can protect patients against diaphragm function damage, improve the success rate of ventilator weaning, and benefit the postoperative outcome, with excellent and rapid sedation effect and less stress damage to patients.Chengda ZhaoMeihua HuangBaiyun WangHuanhui ZhongWen MengHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Chengda Zhao Meihua Huang Baiyun Wang Huanhui Zhong Wen Meng Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation
description	Objective. To probe into the influence of dexmedetomidine (DEX) on diaphragm function and postoperative outcomes of mechanically ventilated patients in the intensive care unit (ICU). Methods. 84 patients with mechanical ventilation (MV) in the ICU of our hospital were selected as the research participants, including 38 patients in the control group (CG) sedated with midazolam (MZ) and 46 patients in the research group (RG) with DEX sedation. Ramsay sedation score, visual analogue scale (VAS), and restlessness score (RS) were used to evaluate their state before sedation (T0), as well as 2 h (T1), 6 h (T2), and 24 h (T3) after sedation, and the alterations of mean arterial pressure (MAP) and heart rate (HR) were recorded. Serum cortisol (Cor), adrenocorticotropic hormone (ACTH), superoxide dismutase (SOD), malondialdehyde (MDA), interleukin- (IL-) 1β, IL-6, and tumor necrosis factor-α (TNF-α) were measured before and 24 h after sedation. The end-inspiratory diaphragm thickness (DTei) and end-expiratory diaphragm thickness (DTee) were measured within 2 h after the initiation of MV and 5 min after the spontaneous breathing test (SBT), and the diaphragm thickening fraction (DTF) was calculated. Finally, the ventilator weaning, MV time, and the incidence of adverse reactions (ADs) of the two groups were counted. Results. T0 and T3 witnessed no distinct difference in Ramsay, VAS, and RS scores between the two arms (P>0.05), but at T1 and T2, RG had better sedation state and lower VAS and RS scores than CG (P<0.05), with more stable vital signs (P<0.05). After sedation, the contents of oxidative stress and inflammatory factors in RG were lower, while DTee, DTei, and DTF were higher, versus CG (P<0.05). Moreover, RG presented higher success rate of first ventilator weaning, less MV time, and lower incidence of ADs than CG (P<0.05). Conclusions. DEX is effective in mechanically ventilated patients in the ICU, which can protect patients against diaphragm function damage, improve the success rate of ventilator weaning, and benefit the postoperative outcome, with excellent and rapid sedation effect and less stress damage to patients.
format	article
author	Chengda Zhao Meihua Huang Baiyun Wang Huanhui Zhong Wen Meng
author_facet	Chengda Zhao Meihua Huang Baiyun Wang Huanhui Zhong Wen Meng
author_sort	Chengda Zhao
title	Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation
title_short	Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation
title_full	Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation
title_fullStr	Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation
title_full_unstemmed	Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation
title_sort	influence of dexmedetomidine on diaphragm function and postoperative outcomes in icu patients with mechanical ventilation
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/e9abbfc950e3439caa005f18ddbf3501
work_keys_str_mv	AT chengdazhao influenceofdexmedetomidineondiaphragmfunctionandpostoperativeoutcomesinicupatientswithmechanicalventilation AT meihuahuang influenceofdexmedetomidineondiaphragmfunctionandpostoperativeoutcomesinicupatientswithmechanicalventilation AT baiyunwang influenceofdexmedetomidineondiaphragmfunctionandpostoperativeoutcomesinicupatientswithmechanicalventilation AT huanhuizhong influenceofdexmedetomidineondiaphragmfunctionandpostoperativeoutcomesinicupatientswithmechanicalventilation AT wenmeng influenceofdexmedetomidineondiaphragmfunctionandpostoperativeoutcomesinicupatientswithmechanicalventilation
_version_	1718443148255952896

Influence of Dexmedetomidine on Diaphragm Function and Postoperative Outcomes in ICU Patients with Mechanical Ventilation

Ejemplares similares