Nitrogen starvation reveals the mitotic potential of mutants in the S/MAPK pathways

Nitrogen-starved fission yeast cells survive for weeks without dividing. Here, the authors show that some of these surviving cells accumulate mutations in the stress- and mitogen-activated protein kinase pathways and outcompete their parental cells, which provide nutrients for the mutant cells.

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Detalles Bibliográficos
Autores principales: Rostyslav Makarenko, Claire Denis, Stefania Francesconi, Serge Gangloff, Benoît Arcangioli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e9ad02e770e946138ceeb1a29db9280c
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Sumario:Nitrogen-starved fission yeast cells survive for weeks without dividing. Here, the authors show that some of these surviving cells accumulate mutations in the stress- and mitogen-activated protein kinase pathways and outcompete their parental cells, which provide nutrients for the mutant cells.