Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

Endocannabinoids are ligands of cannabinoid receptors and a promising target for pain management. Here, the authors report a class of lipids formed by the epoxidation of N-arachidonoyl dopamine and N-arachidonoyl serotonin by cytochrome P450 epoxygenases, which reciprocally regulate canabinoid recep...

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Autores principales:	William R. Arnold, Lauren N. Carnevale, Zili Xie, Javier L. Baylon, Emad Tajkhorshid, Hongzhen Hu, Aditi Das
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9b14b21f1074585aeec1d71675686bb
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spelling	oai:doaj.org-article:e9b14b21f1074585aeec1d71675686bb2021-12-02T14:26:44ZAnti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel10.1038/s41467-021-20946-62041-1723https://doaj.org/article/e9b14b21f1074585aeec1d71675686bb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20946-6https://doaj.org/toc/2041-1723Endocannabinoids are ligands of cannabinoid receptors and a promising target for pain management. Here, the authors report a class of lipids formed by the epoxidation of N-arachidonoyl dopamine and N-arachidonoyl serotonin by cytochrome P450 epoxygenases, which reciprocally regulate canabinoid receptors and display anti-inflammatory activity.William R. ArnoldLauren N. CarnevaleZili XieJavier L. BaylonEmad TajkhorshidHongzhen HuAditi DasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William R. Arnold Lauren N. Carnevale Zili Xie Javier L. Baylon Emad Tajkhorshid Hongzhen Hu Aditi Das Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
description	Endocannabinoids are ligands of cannabinoid receptors and a promising target for pain management. Here, the authors report a class of lipids formed by the epoxidation of N-arachidonoyl dopamine and N-arachidonoyl serotonin by cytochrome P450 epoxygenases, which reciprocally regulate canabinoid receptors and display anti-inflammatory activity.
format	article
author	William R. Arnold Lauren N. Carnevale Zili Xie Javier L. Baylon Emad Tajkhorshid Hongzhen Hu Aditi Das
author_facet	William R. Arnold Lauren N. Carnevale Zili Xie Javier L. Baylon Emad Tajkhorshid Hongzhen Hu Aditi Das
author_sort	William R. Arnold
title	Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
title_short	Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
title_full	Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
title_fullStr	Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
title_full_unstemmed	Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
title_sort	anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the trpv1 channel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9b14b21f1074585aeec1d71675686bb
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Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel

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