Oral Administration of Rosa gallica Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis

Rosa gallica is a widely used Rosa species for medicinal and culinary purposes. Rosa gallica has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of Rosa gallica against skin aging in v...

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Autores principales:	Seongin Jo, Young-Sung Jung, Ye-Ryeong Cho, Ji-Won Seo, Won-Chul Lim, Tae-Gyu Nam, Tae-Gyu Lim, Sanguine Byun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Rosa gallica</i> skin aging gallic acid c−Raf UHPLC−MS/MS Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e9b41b51f7b146d58ed0ef01fa642f75
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spelling	oai:doaj.org-article:e9b41b51f7b146d58ed0ef01fa642f752021-11-25T16:25:36ZOral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis10.3390/antiox101116632076-3921https://doaj.org/article/e9b41b51f7b146d58ed0ef01fa642f752021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1663https://doaj.org/toc/2076-3921<i>Rosa gallica</i> is a widely used Rosa species for medicinal and culinary purposes. <i>Rosa gallica</i> has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of <i>Rosa gallica</i> against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of <i>Rosa gallica</i> prevented UVB−mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that <i>Rosa gallica</i> downregulates UVB−induced COX−2 and MMP−1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC−MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by <i>Rosa gallica</i>. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c−Raf/MEK/ERK/c−Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB−induced MMP−1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, <i>Rosa gallica</i> could be used as a functional ingredient in the development of nutraceuticals against skin aging.Seongin JoYoung-Sung JungYe-Ryeong ChoJi-Won SeoWon-Chul LimTae-Gyu NamTae-Gyu LimSanguine ByunMDPI AGarticle<i>Rosa gallica</i>skin aginggallic acidc−RafUHPLC−MS/MSTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1663, p 1663 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Rosa gallica</i> skin aging gallic acid c−Raf UHPLC−MS/MS Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Rosa gallica</i> skin aging gallic acid c−Raf UHPLC−MS/MS Therapeutics. Pharmacology RM1-950 Seongin Jo Young-Sung Jung Ye-Ryeong Cho Ji-Won Seo Won-Chul Lim Tae-Gyu Nam Tae-Gyu Lim Sanguine Byun Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
description	<i>Rosa gallica</i> is a widely used Rosa species for medicinal and culinary purposes. <i>Rosa gallica</i> has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of <i>Rosa gallica</i> against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of <i>Rosa gallica</i> prevented UVB−mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that <i>Rosa gallica</i> downregulates UVB−induced COX−2 and MMP−1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC−MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by <i>Rosa gallica</i>. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c−Raf/MEK/ERK/c−Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB−induced MMP−1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, <i>Rosa gallica</i> could be used as a functional ingredient in the development of nutraceuticals against skin aging.
format	article
author	Seongin Jo Young-Sung Jung Ye-Ryeong Cho Ji-Won Seo Won-Chul Lim Tae-Gyu Nam Tae-Gyu Lim Sanguine Byun
author_facet	Seongin Jo Young-Sung Jung Ye-Ryeong Cho Ji-Won Seo Won-Chul Lim Tae-Gyu Nam Tae-Gyu Lim Sanguine Byun
author_sort	Seongin Jo
title	Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
title_short	Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
title_full	Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
title_fullStr	Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
title_full_unstemmed	Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis
title_sort	oral administration of <i>rosa gallica</i> prevents uvb−induced skin aging through targeting the c−raf signaling axis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e9b41b51f7b146d58ed0ef01fa642f75
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Oral Administration of <i>Rosa gallica</i> Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis

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