Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells

The second messenger Ap4A contributes to mast cell activation by interacting with HINT1 but the molecular mechanism is not fully understood. Here, the authors show that Ap4A regulates downstream signaling by polymerizing HINT1 and provide insights into how specificity over other second messengers is...

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Autores principales:	Jing Yu, Zaizhou Liu, Yuanyuan Liang, Feng Luo, Jie Zhang, Cuiping Tian, Alex Motzik, Mengmeng Zheng, Jingwu Kang, Guisheng Zhong, Cong Liu, Pengfei Fang, Min Guo, Ehud Razin, Jing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9b4aa0476904a458feec2d841708a19
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spelling	oai:doaj.org-article:e9b4aa0476904a458feec2d841708a192021-12-02T15:35:52ZSecond messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells10.1038/s41467-019-12710-82041-1723https://doaj.org/article/e9b4aa0476904a458feec2d841708a192019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12710-8https://doaj.org/toc/2041-1723The second messenger Ap4A contributes to mast cell activation by interacting with HINT1 but the molecular mechanism is not fully understood. Here, the authors show that Ap4A regulates downstream signaling by polymerizing HINT1 and provide insights into how specificity over other second messengers is achieved.Jing YuZaizhou LiuYuanyuan LiangFeng LuoJie ZhangCuiping TianAlex MotzikMengmeng ZhengJingwu KangGuisheng ZhongCong LiuPengfei FangMin GuoEhud RazinJing WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jing Yu Zaizhou Liu Yuanyuan Liang Feng Luo Jie Zhang Cuiping Tian Alex Motzik Mengmeng Zheng Jingwu Kang Guisheng Zhong Cong Liu Pengfei Fang Min Guo Ehud Razin Jing Wang Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
description	The second messenger Ap4A contributes to mast cell activation by interacting with HINT1 but the molecular mechanism is not fully understood. Here, the authors show that Ap4A regulates downstream signaling by polymerizing HINT1 and provide insights into how specificity over other second messengers is achieved.
format	article
author	Jing Yu Zaizhou Liu Yuanyuan Liang Feng Luo Jie Zhang Cuiping Tian Alex Motzik Mengmeng Zheng Jingwu Kang Guisheng Zhong Cong Liu Pengfei Fang Min Guo Ehud Razin Jing Wang
author_facet	Jing Yu Zaizhou Liu Yuanyuan Liang Feng Luo Jie Zhang Cuiping Tian Alex Motzik Mengmeng Zheng Jingwu Kang Guisheng Zhong Cong Liu Pengfei Fang Min Guo Ehud Razin Jing Wang
author_sort	Jing Yu
title	Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
title_short	Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
title_full	Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
title_fullStr	Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
title_full_unstemmed	Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
title_sort	second messenger ap4a polymerizes target protein hint1 to transduce signals in fcεri-activated mast cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e9b4aa0476904a458feec2d841708a19
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Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells

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