Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells

The second messenger Ap4A contributes to mast cell activation by interacting with HINT1 but the molecular mechanism is not fully understood. Here, the authors show that Ap4A regulates downstream signaling by polymerizing HINT1 and provide insights into how specificity over other second messengers is...

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Autores principales: Jing Yu, Zaizhou Liu, Yuanyuan Liang, Feng Luo, Jie Zhang, Cuiping Tian, Alex Motzik, Mengmeng Zheng, Jingwu Kang, Guisheng Zhong, Cong Liu, Pengfei Fang, Min Guo, Ehud Razin, Jing Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/e9b4aa0476904a458feec2d841708a19
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