The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineage
Abstract A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H...
Guardado en:
Autores principales: | Weixuan Li, Horace Hok Yeung Lee, Run Feng Li, Huachen Maria Zhu, Guan Yi, Joseph Sriyal Malik Peiris, Zi Feng Yang, Chris Ka Pun Mok |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e9b5ef361fee4efdbb2524522a1eafef |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Pathogenicity of the Novel A/H7N9 Influenza Virus in Mice
por: Chris Ka Pun Mok, et al.
Publicado: (2013) -
Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals
por: Libin Liang, et al.
Publicado: (2019) -
Acta Nº627
por: Banco Central de Chile
Publicado: (2019) -
The Emergence and Zoonotic Transmission of H10Nx Avian Influenza Virus Infections
por: Holly Everest, et al.
Publicado: (2021) -
The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase
por: Brett W. Jagger, et al.
Publicado: (2010)