Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography

AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to de...

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Autores principales:	Jing-Wen Jiang, Zuo-Hui-Zi Yi, Xiao-Ling Wang, Jue-Jun Liu, Gong-Peng Sun, Chang-Zheng Chen
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	ultra-widefield fluorescein angiography retinal vasculature imaging Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e9b6554968f6479cbaec85c590799ffa
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spelling	oai:doaj.org-article:e9b6554968f6479cbaec85c590799ffa2021-11-26T04:02:12ZQuantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography2222-39592227-489810.18240/ijo.2021.12.16https://doaj.org/article/e9b6554968f6479cbaec85c590799ffa2021-12-01T00:00:00Zhttp://ies.ijo.cn/en_publish/2021/12/20211216.pdfhttps://doaj.org/toc/2222-3959https://doaj.org/toc/2227-4898AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to define the edge of retinal vasculature by a certified grader. The length from the center of the optic disc to the edge of retinal vascularity (RVL) in each quadrant and the total retinal vascular perfusion area (RVPA) were determined by the grader using OptosAdvance software. The density of retinal vascularity (RVD) was quantified in different zones of central-steered images using Image J software. RESULTS: Among 42 healthy eyes, the values for mean RVL in each quadrant were 19.007±0.781 mm (superior), 18.467±0.869 mm (inferior), 17.738±0.622 mm (nasal) and 24.241±1.336 mm (temporal). The mean RVPA was 1140.117±73.825 mm2. The mean RVD of the total retina was 4.850%±0.638%. RVD varied significantly between different retina zones (P<0.001), and significant differences existed in the RVD values for total retinal area in patients over 50 years old compared to those under 50 years old (P=0.033). No gender difference was found. CONCLUSION: The UWFA device can be a promising tool for analyzing the overall retinal vasculature and may provide a better understanding of retinal vascular morphology in normal eyes. Aging may be related to lower RVD.Jing-Wen JiangZuo-Hui-Zi YiXiao-Ling WangJue-Jun LiuGong-Peng SunChang-Zheng ChenPress of International Journal of Ophthalmology (IJO PRESS)articleultra-widefield fluorescein angiographyretinalvasculatureimagingOphthalmologyRE1-994ENInternational Journal of Ophthalmology, Vol 14, Iss 12, Pp 1915-1920 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultra-widefield fluorescein angiography retinal vasculature imaging Ophthalmology RE1-994
spellingShingle	ultra-widefield fluorescein angiography retinal vasculature imaging Ophthalmology RE1-994 Jing-Wen Jiang Zuo-Hui-Zi Yi Xiao-Ling Wang Jue-Jun Liu Gong-Peng Sun Chang-Zheng Chen Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
description	AIM: To quantify the area and density of retinal vascularity by ultra-widefield fluorescein angiography (UWFA). METHODS: In a retrospective study, UWFA images were obtained using an ultra-widefield imaging device in 42 normal eyes of 42 patients. Central and peripheral steered images were used to define the edge of retinal vasculature by a certified grader. The length from the center of the optic disc to the edge of retinal vascularity (RVL) in each quadrant and the total retinal vascular perfusion area (RVPA) were determined by the grader using OptosAdvance software. The density of retinal vascularity (RVD) was quantified in different zones of central-steered images using Image J software. RESULTS: Among 42 healthy eyes, the values for mean RVL in each quadrant were 19.007±0.781 mm (superior), 18.467±0.869 mm (inferior), 17.738±0.622 mm (nasal) and 24.241±1.336 mm (temporal). The mean RVPA was 1140.117±73.825 mm2. The mean RVD of the total retina was 4.850%±0.638%. RVD varied significantly between different retina zones (P<0.001), and significant differences existed in the RVD values for total retinal area in patients over 50 years old compared to those under 50 years old (P=0.033). No gender difference was found. CONCLUSION: The UWFA device can be a promising tool for analyzing the overall retinal vasculature and may provide a better understanding of retinal vascular morphology in normal eyes. Aging may be related to lower RVD.
format	article
author	Jing-Wen Jiang Zuo-Hui-Zi Yi Xiao-Ling Wang Jue-Jun Liu Gong-Peng Sun Chang-Zheng Chen
author_facet	Jing-Wen Jiang Zuo-Hui-Zi Yi Xiao-Ling Wang Jue-Jun Liu Gong-Peng Sun Chang-Zheng Chen
author_sort	Jing-Wen Jiang
title	Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
title_short	Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
title_full	Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
title_fullStr	Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
title_full_unstemmed	Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
title_sort	quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/e9b6554968f6479cbaec85c590799ffa
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Quantitative analysis of retinal vasculature in normal eyes using ultra-widefield fluorescein angiography

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