Volumetric brain abnormalities in polysubstance use disorder patients

Cemal Onur Noyan,1 Samet Kose,2 Serdar Nurmedov,3 Baris Metin,1 Aslı Enez Darcin,4 Nesrin Dilbaz1 1Department of Psychology, Uskudar University, Istanbul, Turkey; 2Department of Psychiatry and Behavioral Sciences Center for Neurobehavioral Research on Addictions, University of Texas Medical School,...

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Autores principales:	Noyan CO, Kose S, Nurmedov S, Metin B, Darcin AE, Dilbaz N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	early abstinence gray matter volume polysubstance use disorders voxel based morphometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e9b8b3cec26a4a7cb7db8a95093ee06a
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spelling	oai:doaj.org-article:e9b8b3cec26a4a7cb7db8a95093ee06a2021-12-02T11:57:20ZVolumetric brain abnormalities in polysubstance use disorder patients1178-2021https://doaj.org/article/e9b8b3cec26a4a7cb7db8a95093ee06a2016-06-01T00:00:00Zhttps://www.dovepress.com/volumetric-brain-abnormalities-in-polysubstance-use-disorder-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Cemal Onur Noyan,1 Samet Kose,2 Serdar Nurmedov,3 Baris Metin,1 Aslı Enez Darcin,4 Nesrin Dilbaz1 1Department of Psychology, Uskudar University, Istanbul, Turkey; 2Department of Psychiatry and Behavioral Sciences Center for Neurobehavioral Research on Addictions, University of Texas Medical School, Houston, TX, USA; 3Acibadem Healthcare Group, 4Department of Psychiatry, Kanuni Sultan Suleyman Research and Training Hospital, Istanbul, Turkey Aim: Polysubstance users represent the largest group of patients seeking treatment at addiction and rehabilitation clinics in Turkey. There is little knowledge about the structural brain abnormalities seen in polysubstance users. This study was conducted to examine the structural brain differences between polysubstance use disorder patients and healthy control subjects using voxel-based morphometry.Methods: Forty-six male polysubstance use disorder patients in the early abstinence period and 30 healthy male controls underwent structural magnetic resonance imaging scans. Voxel-based morphometry analysis was performed to examine gray matter (GM) abnormality differences.Results: Polysubstance use disorder patients displayed significantly smaller GM volume in the thalamus, temporal pole, superior frontal gyrus, cerebellum, gyrus rectus, occipital lobe, anterior cingulate cortex, superior temporal gyrus, and postcentral gyrus.Conclusion: A widespread and smaller GM volume has been found at different regions of the frontal, temporal, occipital, and parietal lobes, cerebellum, and anterior cingulate cortex in polysubstance users. Keywords: early abstinence, gray matter volume, polysubstance use disorders, voxel-based morphometryNoyan COKose SNurmedov SMetin BDarcin AEDilbaz NDove Medical Pressarticleearly abstinencegray matter volumepolysubstance use disordersvoxel based morphometryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1355-1363 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	early abstinence gray matter volume polysubstance use disorders voxel based morphometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	early abstinence gray matter volume polysubstance use disorders voxel based morphometry Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Noyan CO Kose S Nurmedov S Metin B Darcin AE Dilbaz N Volumetric brain abnormalities in polysubstance use disorder patients
description	Cemal Onur Noyan,1 Samet Kose,2 Serdar Nurmedov,3 Baris Metin,1 Aslı Enez Darcin,4 Nesrin Dilbaz1 1Department of Psychology, Uskudar University, Istanbul, Turkey; 2Department of Psychiatry and Behavioral Sciences Center for Neurobehavioral Research on Addictions, University of Texas Medical School, Houston, TX, USA; 3Acibadem Healthcare Group, 4Department of Psychiatry, Kanuni Sultan Suleyman Research and Training Hospital, Istanbul, Turkey Aim: Polysubstance users represent the largest group of patients seeking treatment at addiction and rehabilitation clinics in Turkey. There is little knowledge about the structural brain abnormalities seen in polysubstance users. This study was conducted to examine the structural brain differences between polysubstance use disorder patients and healthy control subjects using voxel-based morphometry.Methods: Forty-six male polysubstance use disorder patients in the early abstinence period and 30 healthy male controls underwent structural magnetic resonance imaging scans. Voxel-based morphometry analysis was performed to examine gray matter (GM) abnormality differences.Results: Polysubstance use disorder patients displayed significantly smaller GM volume in the thalamus, temporal pole, superior frontal gyrus, cerebellum, gyrus rectus, occipital lobe, anterior cingulate cortex, superior temporal gyrus, and postcentral gyrus.Conclusion: A widespread and smaller GM volume has been found at different regions of the frontal, temporal, occipital, and parietal lobes, cerebellum, and anterior cingulate cortex in polysubstance users. Keywords: early abstinence, gray matter volume, polysubstance use disorders, voxel-based morphometry
format	article
author	Noyan CO Kose S Nurmedov S Metin B Darcin AE Dilbaz N
author_facet	Noyan CO Kose S Nurmedov S Metin B Darcin AE Dilbaz N
author_sort	Noyan CO
title	Volumetric brain abnormalities in polysubstance use disorder patients
title_short	Volumetric brain abnormalities in polysubstance use disorder patients
title_full	Volumetric brain abnormalities in polysubstance use disorder patients
title_fullStr	Volumetric brain abnormalities in polysubstance use disorder patients
title_full_unstemmed	Volumetric brain abnormalities in polysubstance use disorder patients
title_sort	volumetric brain abnormalities in polysubstance use disorder patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/e9b8b3cec26a4a7cb7db8a95093ee06a
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_version_	1718394842629799936

Volumetric brain abnormalities in polysubstance use disorder patients

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