Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Podocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway.

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Autores principales:	Min Liu, Kaili Liang, Junhui Zhen, Meng Zhou, Xiaojie Wang, Ziying Wang, Xinbing Wei, Yan Zhang, Yu Sun, Zhuanli Zhou, Hua Su, Chun Zhang, Ningjun Li, Chengjiang Gao, Jun Peng, Fan Yi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9bf4989decc4c6c98bc0fee37feaa6d
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spelling	oai:doaj.org-article:e9bf4989decc4c6c98bc0fee37feaa6d2021-12-02T15:38:42ZSirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling10.1038/s41467-017-00498-42041-1723https://doaj.org/article/e9bf4989decc4c6c98bc0fee37feaa6d2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00498-4https://doaj.org/toc/2041-1723Podocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway.Min LiuKaili LiangJunhui ZhenMeng ZhouXiaojie WangZiying WangXinbing WeiYan ZhangYu SunZhuanli ZhouHua SuChun ZhangNingjun LiChengjiang GaoJun PengFan YiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Min Liu Kaili Liang Junhui Zhen Meng Zhou Xiaojie Wang Ziying Wang Xinbing Wei Yan Zhang Yu Sun Zhuanli Zhou Hua Su Chun Zhang Ningjun Li Chengjiang Gao Jun Peng Fan Yi Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
description	Podocytes are essential components of the renal glomerular filtration barrier and podocyte dysfunction leads to proteinuric kidney disease. Here Liu et al. show that Sirt6 protects podocytes from apoptosis and inflammation by increasing autophagic flux through inhibition of the Notch pathway.
format	article
author	Min Liu Kaili Liang Junhui Zhen Meng Zhou Xiaojie Wang Ziying Wang Xinbing Wei Yan Zhang Yu Sun Zhuanli Zhou Hua Su Chun Zhang Ningjun Li Chengjiang Gao Jun Peng Fan Yi
author_facet	Min Liu Kaili Liang Junhui Zhen Meng Zhou Xiaojie Wang Ziying Wang Xinbing Wei Yan Zhang Yu Sun Zhuanli Zhou Hua Su Chun Zhang Ningjun Li Chengjiang Gao Jun Peng Fan Yi
author_sort	Min Liu
title	Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
title_short	Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
title_full	Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
title_fullStr	Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
title_full_unstemmed	Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
title_sort	sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting notch signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e9bf4989decc4c6c98bc0fee37feaa6d
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Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

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