Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.

Guardado en:
Detalles Bibliográficos
Autores principales: Sonu Sahadevan, Katharina M. Hembach, Elena Tantardini, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Salim Megat, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e9c043534e61495b8e1dfb249245ca1e
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e9c043534e61495b8e1dfb249245ca1e
record_format dspace
spelling oai:doaj.org-article:e9c043534e61495b8e1dfb249245ca1e2021-12-02T16:51:25ZSynaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS10.1038/s41467-021-23188-82041-1723https://doaj.org/article/e9c043534e61495b8e1dfb249245ca1e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23188-8https://doaj.org/toc/2041-1723Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.Sonu SahadevanKatharina M. HembachElena TantardiniManuela Pérez-BerlangaMarian Hruska-PlochanSalim MegatJulien WeberPetra SchwarzLuc DupuisMark D. RobinsonPierre De RossiMagdalini PolymenidouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sonu Sahadevan
Katharina M. Hembach
Elena Tantardini
Manuela Pérez-Berlanga
Marian Hruska-Plochan
Salim Megat
Julien Weber
Petra Schwarz
Luc Dupuis
Mark D. Robinson
Pierre De Rossi
Magdalini Polymenidou
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
description Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.
format article
author Sonu Sahadevan
Katharina M. Hembach
Elena Tantardini
Manuela Pérez-Berlanga
Marian Hruska-Plochan
Salim Megat
Julien Weber
Petra Schwarz
Luc Dupuis
Mark D. Robinson
Pierre De Rossi
Magdalini Polymenidou
author_facet Sonu Sahadevan
Katharina M. Hembach
Elena Tantardini
Manuela Pérez-Berlanga
Marian Hruska-Plochan
Salim Megat
Julien Weber
Petra Schwarz
Luc Dupuis
Mark D. Robinson
Pierre De Rossi
Magdalini Polymenidou
author_sort Sonu Sahadevan
title Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
title_short Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
title_full Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
title_fullStr Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
title_full_unstemmed Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
title_sort synaptic fus accumulation triggers early misregulation of synaptic rnas in a mouse model of als
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e9c043534e61495b8e1dfb249245ca1e
work_keys_str_mv AT sonusahadevan synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT katharinamhembach synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT elenatantardini synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT manuelaperezberlanga synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT marianhruskaplochan synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT salimmegat synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT julienweber synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT petraschwarz synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT lucdupuis synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT markdrobinson synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT pierrederossi synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
AT magdalinipolymenidou synapticfusaccumulationtriggersearlymisregulationofsynapticrnasinamousemodelofals
_version_ 1718383012840734720

Ejemplares similares