Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS

Mutations in the RNA-binding protein FUS contribute to ALS. Here the authors use CLIP-seq on synaptoneurosomes to identify proteins associated with synapse organization and plasticity that are differentially regulated in a knock-in ALS mouse model.

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Detalles Bibliográficos
Autores principales: Sonu Sahadevan, Katharina M. Hembach, Elena Tantardini, Manuela Pérez-Berlanga, Marian Hruska-Plochan, Salim Megat, Julien Weber, Petra Schwarz, Luc Dupuis, Mark D. Robinson, Pierre De Rossi, Magdalini Polymenidou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/e9c043534e61495b8e1dfb249245ca1e
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