RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment

RelA stimulates RyhB small RNA–target mRNA interaction by promoting assembly of Hfq monomers into hexamers. Here the authors show that RelA-mediated Hfq hexamerization requires an initial binding of RNA to Hfq monomers.

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Autores principales:	Pallabi Basu, Maya Elgrably-Weiss, Fouad Hassouna, Manoj Kumar, Reuven Wiener, Shoshy Altuvia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9c5197e01e44b3fab2266c9e1eaaceb
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spelling	oai:doaj.org-article:e9c5197e01e44b3fab2266c9e1eaaceb2021-12-02T18:28:38ZRNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment10.1038/s41467-021-22553-x2041-1723https://doaj.org/article/e9c5197e01e44b3fab2266c9e1eaaceb2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22553-xhttps://doaj.org/toc/2041-1723RelA stimulates RyhB small RNA–target mRNA interaction by promoting assembly of Hfq monomers into hexamers. Here the authors show that RelA-mediated Hfq hexamerization requires an initial binding of RNA to Hfq monomers.Pallabi BasuMaya Elgrably-WeissFouad HassounaManoj KumarReuven WienerShoshy AltuviaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pallabi Basu Maya Elgrably-Weiss Fouad Hassouna Manoj Kumar Reuven Wiener Shoshy Altuvia RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
description	RelA stimulates RyhB small RNA–target mRNA interaction by promoting assembly of Hfq monomers into hexamers. Here the authors show that RelA-mediated Hfq hexamerization requires an initial binding of RNA to Hfq monomers.
format	article
author	Pallabi Basu Maya Elgrably-Weiss Fouad Hassouna Manoj Kumar Reuven Wiener Shoshy Altuvia
author_facet	Pallabi Basu Maya Elgrably-Weiss Fouad Hassouna Manoj Kumar Reuven Wiener Shoshy Altuvia
author_sort	Pallabi Basu
title	RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
title_short	RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
title_full	RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
title_fullStr	RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
title_full_unstemmed	RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
title_sort	rna binding of hfq monomers promotes rela-mediated hexamerization in a limiting hfq environment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9c5197e01e44b3fab2266c9e1eaaceb
work_keys_str_mv	AT pallabibasu rnabindingofhfqmonomerspromotesrelamediatedhexamerizationinalimitinghfqenvironment AT mayaelgrablyweiss rnabindingofhfqmonomerspromotesrelamediatedhexamerizationinalimitinghfqenvironment AT fouadhassouna rnabindingofhfqmonomerspromotesrelamediatedhexamerizationinalimitinghfqenvironment AT manojkumar rnabindingofhfqmonomerspromotesrelamediatedhexamerizationinalimitinghfqenvironment AT reuvenwiener rnabindingofhfqmonomerspromotesrelamediatedhexamerizationinalimitinghfqenvironment AT shoshyaltuvia rnabindingofhfqmonomerspromotesrelamediatedhexamerizationinalimitinghfqenvironment
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RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment

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