Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice

Abstract Background Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder and characterized by progressive loss of memory and cognitive functions, which are associated with amyloid-beta (Aβ) plaques. Immune cells play an important role in the clearance of Aβ deposits. Immu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Haiyan Liu, Jin Zhao, Yujun Lin, Min Su, Laijun Lai
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Alzheimer’s disease Amyloid-beta ERMAP T cells Macrophage Choroid plexus Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e9c8535663b54d36a5a6cb72c16bd770
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9c8535663b54d36a5a6cb72c16bd770
record_format	dspace
spelling	oai:doaj.org-article:e9c8535663b54d36a5a6cb72c16bd7702021-11-14T12:38:12ZAdministration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice10.1186/s12974-021-02320-x1742-2094https://doaj.org/article/e9c8535663b54d36a5a6cb72c16bd7702021-11-01T00:00:00Zhttps://doi.org/10.1186/s12974-021-02320-xhttps://doaj.org/toc/1742-2094Abstract Background Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder and characterized by progressive loss of memory and cognitive functions, which are associated with amyloid-beta (Aβ) plaques. Immune cells play an important role in the clearance of Aβ deposits. Immune responses are regulated by immune regulators in which the B7 family members play a crucial role. We have recently identified erythroid membrane-associated protein (ERMAP) as a novel B7 family-related immune regulator and shown that ERMAP protein affects T cell and macrophage functions. Methods We produced a monoclonal antibody (mAb) against ERMAP protein and then determined the ability of the mAb to affect cognitive performance and AD pathology in mice. Results We have shown that the anti-ERMAP mAb neutralizes the T cell inhibitory activity of ERMAP and enhances macrophages to phagocytose Aβ in vitro. Administration of the mAb into AD mice improves cognitive performance and reduces Aβ plaque load in the brain. This is related to increased proportion of T cells, especially IFNγ-producing T cells, in the spleen and the choroid plexus (CP), enhanced expression of immune cell trafficking molecules in the CP, and increased migration of monocyte-derived macrophages into the brain. Furthermore, the production of anti-Aβ antibodies in the serum and the macrophage phagocytosis of Aβ are enhanced in the anti-ERMAP mAb-treated AD mice. Conclusions Our results suggest that manipulating the ERMAP pathway has the potential to provide a novel approach to treat AD patients.Haiyan LiuJin ZhaoYujun LinMin SuLaijun LaiBMCarticleAlzheimer’s diseaseAmyloid-betaERMAPT cellsMacrophageChoroid plexusNeurology. Diseases of the nervous systemRC346-429ENJournal of Neuroinflammation, Vol 18, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease Amyloid-beta ERMAP T cells Macrophage Choroid plexus Neurology. Diseases of the nervous system RC346-429
spellingShingle	Alzheimer’s disease Amyloid-beta ERMAP T cells Macrophage Choroid plexus Neurology. Diseases of the nervous system RC346-429 Haiyan Liu Jin Zhao Yujun Lin Min Su Laijun Lai Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
description	Abstract Background Alzheimer’s disease (AD) is a devastating age-related neurodegenerative disorder and characterized by progressive loss of memory and cognitive functions, which are associated with amyloid-beta (Aβ) plaques. Immune cells play an important role in the clearance of Aβ deposits. Immune responses are regulated by immune regulators in which the B7 family members play a crucial role. We have recently identified erythroid membrane-associated protein (ERMAP) as a novel B7 family-related immune regulator and shown that ERMAP protein affects T cell and macrophage functions. Methods We produced a monoclonal antibody (mAb) against ERMAP protein and then determined the ability of the mAb to affect cognitive performance and AD pathology in mice. Results We have shown that the anti-ERMAP mAb neutralizes the T cell inhibitory activity of ERMAP and enhances macrophages to phagocytose Aβ in vitro. Administration of the mAb into AD mice improves cognitive performance and reduces Aβ plaque load in the brain. This is related to increased proportion of T cells, especially IFNγ-producing T cells, in the spleen and the choroid plexus (CP), enhanced expression of immune cell trafficking molecules in the CP, and increased migration of monocyte-derived macrophages into the brain. Furthermore, the production of anti-Aβ antibodies in the serum and the macrophage phagocytosis of Aβ are enhanced in the anti-ERMAP mAb-treated AD mice. Conclusions Our results suggest that manipulating the ERMAP pathway has the potential to provide a novel approach to treat AD patients.
format	article
author	Haiyan Liu Jin Zhao Yujun Lin Min Su Laijun Lai
author_facet	Haiyan Liu Jin Zhao Yujun Lin Min Su Laijun Lai
author_sort	Haiyan Liu
title	Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
title_short	Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
title_full	Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
title_fullStr	Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
title_full_unstemmed	Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice
title_sort	administration of anti-ermap antibody ameliorates alzheimer’s disease in mice
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e9c8535663b54d36a5a6cb72c16bd770
work_keys_str_mv	AT haiyanliu administrationofantiermapantibodyamelioratesalzheimersdiseaseinmice AT jinzhao administrationofantiermapantibodyamelioratesalzheimersdiseaseinmice AT yujunlin administrationofantiermapantibodyamelioratesalzheimersdiseaseinmice AT minsu administrationofantiermapantibodyamelioratesalzheimersdiseaseinmice AT laijunlai administrationofantiermapantibodyamelioratesalzheimersdiseaseinmice
_version_	1718429141628354560

Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice

Ejemplares similares