Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort

Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources.

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Auteurs principaux:	Markus Jeschek, Daniel Gerngross, Sven Panke
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e9c8e8a8f07c4ecbac79a4d985f6ac3a
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id	oai:doaj.org-article:e9c8e8a8f07c4ecbac79a4d985f6ac3a
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spelling	oai:doaj.org-article:e9c8e8a8f07c4ecbac79a4d985f6ac3a2021-12-02T15:34:59ZRationally reduced libraries for combinatorial pathway optimization minimizing experimental effort10.1038/ncomms111632041-1723https://doaj.org/article/e9c8e8a8f07c4ecbac79a4d985f6ac3a2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms11163https://doaj.org/toc/2041-1723Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources.Markus JeschekDaniel GerngrossSven PankeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Markus Jeschek Daniel Gerngross Sven Panke Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
description	Rational design in metabolic engineering is often difficult and limited to small screens, favouring construction of compressed smart libraries. Here the authors introduce RedLibs, an algorithm to design combinatorial RBS libraries to allow pathway optimization with minimal experimental resources.
format	article
author	Markus Jeschek Daniel Gerngross Sven Panke
author_facet	Markus Jeschek Daniel Gerngross Sven Panke
author_sort	Markus Jeschek
title	Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
title_short	Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
title_full	Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
title_fullStr	Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
title_full_unstemmed	Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
title_sort	rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e9c8e8a8f07c4ecbac79a4d985f6ac3a
work_keys_str_mv	AT markusjeschek rationallyreducedlibrariesforcombinatorialpathwayoptimizationminimizingexperimentaleffort AT danielgerngross rationallyreducedlibrariesforcombinatorialpathwayoptimizationminimizingexperimentaleffort AT svenpanke rationallyreducedlibrariesforcombinatorialpathwayoptimizationminimizingexperimentaleffort
_version_	1718386692710203392

Rationally reduced libraries for combinatorial pathway optimization minimizing experimental effort

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