A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Temozolomide (TMZ) resistance in glioblastomas (GBM) is associated with increased MGMT expression. Here, the authors identify an enhancer between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methylation to confer TMZ resistance in GBM.

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Autores principales:	Xiaoyue Chen, Minjie Zhang, Haiyun Gan, Heping Wang, Jeong-Heon Lee, Dong Fang, Gaspar J. Kitange, Lihong He, Zeng Hu, Ian F. Parney, Fredric B. Meyer, Caterina Giannini, Jann N. Sarkaria, Zhiguo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9cbaa57340b40429d4d685a036a322c
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spelling	oai:doaj.org-article:e9cbaa57340b40429d4d685a036a322c2021-12-02T14:40:05ZA novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma10.1038/s41467-018-05373-42041-1723https://doaj.org/article/e9cbaa57340b40429d4d685a036a322c2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05373-4https://doaj.org/toc/2041-1723Temozolomide (TMZ) resistance in glioblastomas (GBM) is associated with increased MGMT expression. Here, the authors identify an enhancer between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methylation to confer TMZ resistance in GBM.Xiaoyue ChenMinjie ZhangHaiyun GanHeping WangJeong-Heon LeeDong FangGaspar J. KitangeLihong HeZeng HuIan F. ParneyFredric B. MeyerCaterina GianniniJann N. SarkariaZhiguo ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyue Chen Minjie Zhang Haiyun Gan Heping Wang Jeong-Heon Lee Dong Fang Gaspar J. Kitange Lihong He Zeng Hu Ian F. Parney Fredric B. Meyer Caterina Giannini Jann N. Sarkaria Zhiguo Zhang A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
description	Temozolomide (TMZ) resistance in glioblastomas (GBM) is associated with increased MGMT expression. Here, the authors identify an enhancer between the promoters of MKI67 and MGMT, that when activated drives MGMT expression despite MGMT promoter methylation to confer TMZ resistance in GBM.
format	article
author	Xiaoyue Chen Minjie Zhang Haiyun Gan Heping Wang Jeong-Heon Lee Dong Fang Gaspar J. Kitange Lihong He Zeng Hu Ian F. Parney Fredric B. Meyer Caterina Giannini Jann N. Sarkaria Zhiguo Zhang
author_facet	Xiaoyue Chen Minjie Zhang Haiyun Gan Heping Wang Jeong-Heon Lee Dong Fang Gaspar J. Kitange Lihong He Zeng Hu Ian F. Parney Fredric B. Meyer Caterina Giannini Jann N. Sarkaria Zhiguo Zhang
author_sort	Xiaoyue Chen
title	A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
title_short	A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
title_full	A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
title_fullStr	A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
title_full_unstemmed	A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
title_sort	novel enhancer regulates mgmt expression and promotes temozolomide resistance in glioblastoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e9cbaa57340b40429d4d685a036a322c
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A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

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