A Mouse Model for <italic toggle="yes">Betacoronavirus</italic> Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

A Mouse Model for <italic toggle="yes">Betacoronavirus</italic> Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

ABSTRACT Cross-species transmission of zoonotic coronaviruses (CoVs) can result in pandemic disease outbreaks. Middle East respiratory syndrome CoV (MERS-CoV), identified in 2012, has caused 182 cases to date, with ~43% mortality, and no small animal model has been reported. MERS-CoV and Pipistrellu...

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Autores principales: Sudhakar Agnihothram, Boyd L. Yount, Eric F. Donaldson, Jeremy Huynh, Vineet D. Menachery, Lisa E. Gralinski, Rachel L. Graham, Michelle M. Becker, Sakshi Tomar, Trevor D. Scobey, Heather L. Osswald, Alan Whitmore, Robin Gopal, Arun K. Ghosh, Andrew Mesecar, Maria Zambon, Mark Heise, Mark R. Denison, Ralph S. Baric
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2014
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e9cfa1a0b1b145eba9f257143e0e07a0
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