Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy

Zhonglun Chen, Mouxiao Su, Zhaokun Li, Hongcai Du, Shanshan Zhang, Mingjun Pu, Yun Zhang Department of Neurology, MianYang Central Hospital, Mianyang, Sichuan 621000, People’s Republic of ChinaCorrespondence: Yun ZhangDepartment of Neurology, Mianyang Central Hospital, 12 Changjia Alley, M...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Chen Z, Su M, Li Z, Du H, Zhang S, Pu M, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	metabolic syndrome ischemic stroke endovascular thrombectomy prognosis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e9d3b0150e1c43ffa6deefb7d3775cc3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9d3b0150e1c43ffa6deefb7d3775cc3
record_format	dspace
spelling	oai:doaj.org-article:e9d3b0150e1c43ffa6deefb7d3775cc32021-12-02T09:09:34ZMetabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy1178-2021https://doaj.org/article/e9d3b0150e1c43ffa6deefb7d3775cc32020-09-01T00:00:00Zhttps://www.dovepress.com/metabolic-syndrome-predicts-poor-outcome-in-acute-ischemic-stroke-pati-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhonglun Chen, Mouxiao Su, Zhaokun Li, Hongcai Du, Shanshan Zhang, Mingjun Pu, Yun Zhang Department of Neurology, MianYang Central Hospital, Mianyang, Sichuan 621000, People’s Republic of ChinaCorrespondence: Yun ZhangDepartment of Neurology, Mianyang Central Hospital, 12 Changjia Alley, Mianyang, Sichuan Province 621000, People’s Republic of ChinaTel/ Fax +86 816-2246359Email zhangyun_neuro@126.comBackground and Aims: The metabolic syndrome (MetS) is believed to contribute to a higher probability of developing cardiovascular diseases. This study aimed to investigate whether MetS could predict the prognosis in ischemic stroke patients after endovascular thrombectomy (EVT).Methods: Between January 2016 and September 2019, patients treated with EVT due to large vessel occlusions in anterior circulation were prospectively recruited. MetS was defined using the International Diabetes Federation criteria after admission. The primary outcome was a 3-month poor outcome (modified Rankin scale score of 3– 6). Secondary outcomes included symptomatic intracranial hemorrhage (sICH) and mortality at 3 months. Multivariable logistic regression models were used to assess the relationship between MetS and clinical outcomes.Results: A total of 248 patients were enrolled (mean age, 66.7 years; 37.5% female) and 114 (46.0%) met with the MetS criteria. The median National Institutes of Health Stroke Scale score was 15.0. There were 131 (52.8%) patients achieving the poor outcome at 3 months, among which 26 (10.5%) patients developed sICH. The mortality at 3 months was 19.0% (47/248). In multivariable analysis, MetS was significantly correlated to poor outcome (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.29– 4.78, P = 0.014). The risk for poor outcome was positively associated with the increased number of MetS components (OR 1.78; 95% CI 1.39– 2.35, P = 0.001). No significant findings were found in the association of MetS with sICH and mortality.Conclusion: Our data demonstrated that MetS was associated with poor prognosis in acute ischemic patients treated with EVT.Keywords: metabolic syndrome, ischemic stroke, endovascular thrombectomy, prognosisChen ZSu MLi ZDu HZhang SPu MZhang YDove Medical Pressarticlemetabolic syndromeischemic strokeendovascular thrombectomyprognosis.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2045-2052 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic syndrome ischemic stroke endovascular thrombectomy prognosis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	metabolic syndrome ischemic stroke endovascular thrombectomy prognosis. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen Z Su M Li Z Du H Zhang S Pu M Zhang Y Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
description	Zhonglun Chen, Mouxiao Su, Zhaokun Li, Hongcai Du, Shanshan Zhang, Mingjun Pu, Yun Zhang Department of Neurology, MianYang Central Hospital, Mianyang, Sichuan 621000, People’s Republic of ChinaCorrespondence: Yun ZhangDepartment of Neurology, Mianyang Central Hospital, 12 Changjia Alley, Mianyang, Sichuan Province 621000, People’s Republic of ChinaTel/ Fax +86 816-2246359Email zhangyun_neuro@126.comBackground and Aims: The metabolic syndrome (MetS) is believed to contribute to a higher probability of developing cardiovascular diseases. This study aimed to investigate whether MetS could predict the prognosis in ischemic stroke patients after endovascular thrombectomy (EVT).Methods: Between January 2016 and September 2019, patients treated with EVT due to large vessel occlusions in anterior circulation were prospectively recruited. MetS was defined using the International Diabetes Federation criteria after admission. The primary outcome was a 3-month poor outcome (modified Rankin scale score of 3– 6). Secondary outcomes included symptomatic intracranial hemorrhage (sICH) and mortality at 3 months. Multivariable logistic regression models were used to assess the relationship between MetS and clinical outcomes.Results: A total of 248 patients were enrolled (mean age, 66.7 years; 37.5% female) and 114 (46.0%) met with the MetS criteria. The median National Institutes of Health Stroke Scale score was 15.0. There were 131 (52.8%) patients achieving the poor outcome at 3 months, among which 26 (10.5%) patients developed sICH. The mortality at 3 months was 19.0% (47/248). In multivariable analysis, MetS was significantly correlated to poor outcome (odds ratio [OR], 2.48; 95% confidence interval [CI], 1.29– 4.78, P = 0.014). The risk for poor outcome was positively associated with the increased number of MetS components (OR 1.78; 95% CI 1.39– 2.35, P = 0.001). No significant findings were found in the association of MetS with sICH and mortality.Conclusion: Our data demonstrated that MetS was associated with poor prognosis in acute ischemic patients treated with EVT.Keywords: metabolic syndrome, ischemic stroke, endovascular thrombectomy, prognosis
format	article
author	Chen Z Su M Li Z Du H Zhang S Pu M Zhang Y
author_facet	Chen Z Su M Li Z Du H Zhang S Pu M Zhang Y
author_sort	Chen Z
title	Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
title_short	Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
title_full	Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
title_fullStr	Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
title_full_unstemmed	Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
title_sort	metabolic syndrome predicts poor outcome in acute ischemic stroke patients after endovascular thrombectomy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e9d3b0150e1c43ffa6deefb7d3775cc3
work_keys_str_mv	AT chenz metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy AT sum metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy AT liz metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy AT duh metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy AT zhangs metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy AT pum metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy AT zhangy metabolicsyndromepredictspooroutcomeinacuteischemicstrokepatientsafterendovascularthrombectomy
_version_	1718398277983928320

Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy

Ejemplares similares