Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study

Abstract Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (...

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Autores principales:	Ling Yeung, Chi-Chun Lai, San-Ni Chen, Cheng-Kuo Cheng, Chung-May Yang, Yi-Ting Hsieh, Arslan Tsai, Chang-Hao Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9d5bca02b8c40ecb7b9b5a7a841f401
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spelling	oai:doaj.org-article:e9d5bca02b8c40ecb7b9b5a7a841f4012021-12-02T14:01:37ZComparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study10.1038/s41598-020-80731-12045-2322https://doaj.org/article/e9d5bca02b8c40ecb7b9b5a7a841f4012021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80731-1https://doaj.org/toc/2045-2322Abstract Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes through retrospective review of indocyanine green angiography (ICGA) and fluorescein angiography images from two observational studies (RENOWNED/REAL). Of the visual outcomes for each angiographic subtype and treatment pattern investigated, BVN was identified in 56.3% of PCV patients. The proportions and features of the re-defined PCV subtypes were 43.8%, 10.4%, and 45.8% for subtype A (without distinctive features of BVN), B (with BVN but no leakage), and C (with BVN and leakage), respectively. Subtype A had better visual outcomes when compared to subtype C. This possibly resulted from a better baseline visual acuity in subtype A. Moreover, combination therapy [photodynamic therapy plus anti-vascular endothelial growth factor (VEGF)] may lead to better visual improvement than mono-anti-VEGF treatment alone. This study provides the prevalence of PCV subtypes in Taiwan and may serve as a reference for PCV treatment strategies in a real-world setting, especially for the combination therapy and patients without distinctive features of BVN.Ling YeungChi-Chun LaiSan-Ni ChenCheng-Kuo ChengChung-May YangYi-Ting HsiehArslan TsaiChang-Hao YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ling Yeung Chi-Chun Lai San-Ni Chen Cheng-Kuo Cheng Chung-May Yang Yi-Ting Hsieh Arslan Tsai Chang-Hao Yang Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
description	Abstract Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes through retrospective review of indocyanine green angiography (ICGA) and fluorescein angiography images from two observational studies (RENOWNED/REAL). Of the visual outcomes for each angiographic subtype and treatment pattern investigated, BVN was identified in 56.3% of PCV patients. The proportions and features of the re-defined PCV subtypes were 43.8%, 10.4%, and 45.8% for subtype A (without distinctive features of BVN), B (with BVN but no leakage), and C (with BVN and leakage), respectively. Subtype A had better visual outcomes when compared to subtype C. This possibly resulted from a better baseline visual acuity in subtype A. Moreover, combination therapy [photodynamic therapy plus anti-vascular endothelial growth factor (VEGF)] may lead to better visual improvement than mono-anti-VEGF treatment alone. This study provides the prevalence of PCV subtypes in Taiwan and may serve as a reference for PCV treatment strategies in a real-world setting, especially for the combination therapy and patients without distinctive features of BVN.
format	article
author	Ling Yeung Chi-Chun Lai San-Ni Chen Cheng-Kuo Cheng Chung-May Yang Yi-Ting Hsieh Arslan Tsai Chang-Hao Yang
author_facet	Ling Yeung Chi-Chun Lai San-Ni Chen Cheng-Kuo Cheng Chung-May Yang Yi-Ting Hsieh Arslan Tsai Chang-Hao Yang
author_sort	Ling Yeung
title	Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
title_short	Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
title_full	Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
title_fullStr	Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
title_full_unstemmed	Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study
title_sort	comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (pcv) in taiwan: a real-world study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9d5bca02b8c40ecb7b9b5a7a841f401
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Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study

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