Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry

Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.

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Autores principales:	Amit Kulkarni, Tiago Ferreira, Clemens Bretscher, Annabel Grewenig, Nazim El-Andaloussi, Serena Bonifati, Tiina Marttila, Valérie Palissot, Jubayer A. Hossain, Francisco Azuaje, Hrvoje Miletic, Lars A. R. Ystaas, Anna Golebiewska, Simone P. Niclou, Ralf Roeth, Beate Niesler, Amélie Weiss, Laurent Brino, Antonio Marchini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9d685fa483d413282b0592f44b963bf
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spelling	oai:doaj.org-article:e9d685fa483d413282b0592f44b963bf2021-12-02T17:45:15ZOncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry10.1038/s41467-021-24034-72041-1723https://doaj.org/article/e9d685fa483d413282b0592f44b963bf2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24034-7https://doaj.org/toc/2041-1723Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.Amit KulkarniTiago FerreiraClemens BretscherAnnabel GrewenigNazim El-AndaloussiSerena BonifatiTiina MarttilaValérie PalissotJubayer A. HossainFrancisco AzuajeHrvoje MileticLars A. R. YstaasAnna GolebiewskaSimone P. NiclouRalf RoethBeate NieslerAmélie WeissLaurent BrinoAntonio MarchiniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amit Kulkarni Tiago Ferreira Clemens Bretscher Annabel Grewenig Nazim El-Andaloussi Serena Bonifati Tiina Marttila Valérie Palissot Jubayer A. Hossain Francisco Azuaje Hrvoje Miletic Lars A. R. Ystaas Anna Golebiewska Simone P. Niclou Ralf Roeth Beate Niesler Amélie Weiss Laurent Brino Antonio Marchini Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
description	Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.
format	article
author	Amit Kulkarni Tiago Ferreira Clemens Bretscher Annabel Grewenig Nazim El-Andaloussi Serena Bonifati Tiina Marttila Valérie Palissot Jubayer A. Hossain Francisco Azuaje Hrvoje Miletic Lars A. R. Ystaas Anna Golebiewska Simone P. Niclou Ralf Roeth Beate Niesler Amélie Weiss Laurent Brino Antonio Marchini
author_facet	Amit Kulkarni Tiago Ferreira Clemens Bretscher Annabel Grewenig Nazim El-Andaloussi Serena Bonifati Tiina Marttila Valérie Palissot Jubayer A. Hossain Francisco Azuaje Hrvoje Miletic Lars A. R. Ystaas Anna Golebiewska Simone P. Niclou Ralf Roeth Beate Niesler Amélie Weiss Laurent Brino Antonio Marchini
author_sort	Amit Kulkarni
title	Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
title_short	Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
title_full	Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
title_fullStr	Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
title_full_unstemmed	Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
title_sort	oncolytic h-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9d685fa483d413282b0592f44b963bf
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Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry

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