The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer

The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer

Castration resistant prostate cancer patients treated with enzalutamide may develop resistance to the drug. Here, the authors report that monoamine oxidase-A expression is increased in these resistant tumors and that the antidepressants phenelzine/clorgyline can reverse such resistance to further su...

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Autores principales: Keliang Wang, Jie Luo, Shuyuan Yeh, Bosen You, Jialin Meng, Philip Chang, Yuanjie Niu, Gonghui Li, Changxue Lu, Yezi Zhu, Emmanuel S. Antonarakis, Jun Luo, Chi-Ping Huang, Wanhai Xu, Chawnshang Chang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e9d6def113e84a60bc881fcbffc3cdfb
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spelling oai:doaj.org-article:e9d6def113e84a60bc881fcbffc3cdfb2021-12-02T18:24:58ZThe MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer10.1038/s41467-020-15396-52041-1723https://doaj.org/article/e9d6def113e84a60bc881fcbffc3cdfb2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15396-5https://doaj.org/toc/2041-1723Castration resistant prostate cancer patients treated with enzalutamide may develop resistance to the drug. Here, the authors report that monoamine oxidase-A expression is increased in these resistant tumors and that the antidepressants phenelzine/clorgyline can reverse such resistance to further suppress tumor growthKeliang WangJie LuoShuyuan YehBosen YouJialin MengPhilip ChangYuanjie NiuGonghui LiChangxue LuYezi ZhuEmmanuel S. AntonarakisJun LuoChi-Ping HuangWanhai XuChawnshang ChangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Keliang Wang
Jie Luo
Shuyuan Yeh
Bosen You
Jialin Meng
Philip Chang
Yuanjie Niu
Gonghui Li
Changxue Lu
Yezi Zhu
Emmanuel S. Antonarakis
Jun Luo
Chi-Ping Huang
Wanhai Xu
Chawnshang Chang
The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
description Castration resistant prostate cancer patients treated with enzalutamide may develop resistance to the drug. Here, the authors report that monoamine oxidase-A expression is increased in these resistant tumors and that the antidepressants phenelzine/clorgyline can reverse such resistance to further suppress tumor growth
format article
author Keliang Wang
Jie Luo
Shuyuan Yeh
Bosen You
Jialin Meng
Philip Chang
Yuanjie Niu
Gonghui Li
Changxue Lu
Yezi Zhu
Emmanuel S. Antonarakis
Jun Luo
Chi-Ping Huang
Wanhai Xu
Chawnshang Chang
author_facet Keliang Wang
Jie Luo
Shuyuan Yeh
Bosen You
Jialin Meng
Philip Chang
Yuanjie Niu
Gonghui Li
Changxue Lu
Yezi Zhu
Emmanuel S. Antonarakis
Jun Luo
Chi-Ping Huang
Wanhai Xu
Chawnshang Chang
author_sort Keliang Wang
title The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
title_short The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
title_full The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
title_fullStr The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
title_full_unstemmed The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
title_sort mao inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/e9d6def113e84a60bc881fcbffc3cdfb
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