Sperm Associated Antigens: Vigorous Influencers in Life

Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have expl...

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Auteurs principaux: Samaneh Faraji, Mohsen Sharafi, Abdolhossein Shahverdi, Rouhollah Fathi
Format: article
Langue:EN
Publié: Royan Institute (ACECR), Tehran 2021
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Accès en ligne:https://doaj.org/article/e9d8922f49e44cb1a43819c2605121bd
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spelling oai:doaj.org-article:e9d8922f49e44cb1a43819c2605121bd2021-11-07T06:49:45ZSperm Associated Antigens: Vigorous Influencers in Life10.22074/cellj.2021.73772228-58062228-5814https://doaj.org/article/e9d8922f49e44cb1a43819c2605121bd2021-11-01T00:00:00Zhttps://celljournal.org/journal/article/fulltext/sperm-associated-antigens-vigorous-influencers-in-life.pdfhttps://doaj.org/toc/2228-5806https://doaj.org/toc/2228-5814Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.Samaneh FarajiMohsen SharafiAbdolhossein ShahverdiRouhollah FathiRoyan Institute (ACECR), TehranarticleantigencancerfertilityhumanspermMedicineRScienceQENCell Journal, Vol 23, Iss 5, Pp 495-502 (2021)
institution DOAJ
collection DOAJ
language EN
topic antigen
cancer
fertility
human
sperm
Medicine
R
Science
Q
spellingShingle antigen
cancer
fertility
human
sperm
Medicine
R
Science
Q
Samaneh Faraji
Mohsen Sharafi
Abdolhossein Shahverdi
Rouhollah Fathi
Sperm Associated Antigens: Vigorous Influencers in Life
description Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.
format article
author Samaneh Faraji
Mohsen Sharafi
Abdolhossein Shahverdi
Rouhollah Fathi
author_facet Samaneh Faraji
Mohsen Sharafi
Abdolhossein Shahverdi
Rouhollah Fathi
author_sort Samaneh Faraji
title Sperm Associated Antigens: Vigorous Influencers in Life
title_short Sperm Associated Antigens: Vigorous Influencers in Life
title_full Sperm Associated Antigens: Vigorous Influencers in Life
title_fullStr Sperm Associated Antigens: Vigorous Influencers in Life
title_full_unstemmed Sperm Associated Antigens: Vigorous Influencers in Life
title_sort sperm associated antigens: vigorous influencers in life
publisher Royan Institute (ACECR), Tehran
publishDate 2021
url https://doaj.org/article/e9d8922f49e44cb1a43819c2605121bd
work_keys_str_mv AT samanehfaraji spermassociatedantigensvigorousinfluencersinlife
AT mohsensharafi spermassociatedantigensvigorousinfluencersinlife
AT abdolhosseinshahverdi spermassociatedantigensvigorousinfluencersinlife
AT rouhollahfathi spermassociatedantigensvigorousinfluencersinlife
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