Sperm Associated Antigens: Vigorous Influencers in Life

Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have expl...

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Main Authors:	Samaneh Faraji, Mohsen Sharafi, Abdolhossein Shahverdi, Rouhollah Fathi
Format:	article
Language:	EN
Published:	Royan Institute (ACECR), Tehran 2021
Subjects:	antigen cancer fertility human sperm Medicine R Science Q
Online Access:	https://doaj.org/article/e9d8922f49e44cb1a43819c2605121bd
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spelling	oai:doaj.org-article:e9d8922f49e44cb1a43819c2605121bd2021-11-07T06:49:45ZSperm Associated Antigens: Vigorous Influencers in Life10.22074/cellj.2021.73772228-58062228-5814https://doaj.org/article/e9d8922f49e44cb1a43819c2605121bd2021-11-01T00:00:00Zhttps://celljournal.org/journal/article/fulltext/sperm-associated-antigens-vigorous-influencers-in-life.pdfhttps://doaj.org/toc/2228-5806https://doaj.org/toc/2228-5814Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.Samaneh FarajiMohsen SharafiAbdolhossein ShahverdiRouhollah FathiRoyan Institute (ACECR), TehranarticleantigencancerfertilityhumanspermMedicineRScienceQENCell Journal, Vol 23, Iss 5, Pp 495-502 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antigen cancer fertility human sperm Medicine R Science Q
spellingShingle	antigen cancer fertility human sperm Medicine R Science Q Samaneh Faraji Mohsen Sharafi Abdolhossein Shahverdi Rouhollah Fathi Sperm Associated Antigens: Vigorous Influencers in Life
description	Sperm associated antigens (SPAGs) are specific proteins in terms of performance and evolution, that have common expressions in the testes or sperm cells. Moreover, the humoral immune response against some of SPAGs can result in immunological infertilities. On the other hand, recent studies have explored several new properties of SPAGs and shed light on sperm's function, the impact of anti-sperm antibodies (ASA) in immunological infertility, and some tumors related to SPAGs. This article presents an exhaustive review of SPAGs and their roles in the cell cycle, signaling pathways, fertility, sperm-oocyte cross-talk as well as their unfavorable positions as prognostic factors in many types of cancers.
format	article
author	Samaneh Faraji Mohsen Sharafi Abdolhossein Shahverdi Rouhollah Fathi
author_facet	Samaneh Faraji Mohsen Sharafi Abdolhossein Shahverdi Rouhollah Fathi
author_sort	Samaneh Faraji
title	Sperm Associated Antigens: Vigorous Influencers in Life
title_short	Sperm Associated Antigens: Vigorous Influencers in Life
title_full	Sperm Associated Antigens: Vigorous Influencers in Life
title_fullStr	Sperm Associated Antigens: Vigorous Influencers in Life
title_full_unstemmed	Sperm Associated Antigens: Vigorous Influencers in Life
title_sort	sperm associated antigens: vigorous influencers in life
publisher	Royan Institute (ACECR), Tehran
publishDate	2021
url	https://doaj.org/article/e9d8922f49e44cb1a43819c2605121bd
work_keys_str_mv	AT samanehfaraji spermassociatedantigensvigorousinfluencersinlife AT mohsensharafi spermassociatedantigensvigorousinfluencersinlife AT abdolhosseinshahverdi spermassociatedantigensvigorousinfluencersinlife AT rouhollahfathi spermassociatedantigensvigorousinfluencersinlife
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Sperm Associated Antigens: Vigorous Influencers in Life

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